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Dev Dyn 2006 Aug 01;2358:2083-94. doi: 10.1002/dvdy.20874.
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Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation.

Du Pasquier D , Rincheval V , Sinzelle L , Chesneau A , Ballagny C , Sachs LM , Demeneix B , Mazabraud A .

Elimination of tadpole organs during Xenopus metamorphosis is largely achieved through apoptosis, and recent evidence suggest involvement of the mitochondrial death route and bax-initiated caspase-3 and -9 deployment. However, events upstream of the activation of Bax are unknown. In other models, proteins of the BH3-only group such as BID are known to assure this function. We show that Xenopus bid transcript levels increase at metamorphosis in larval cells destined to disappear. This increase correlates with an abrupt rise in Caspase-2 and -8 mRNA levels and an enhanced activity of Caspase-2 and -8. In BIDGFP transgenic animal's tail regression is accelerated. The cleavage of BIDGFP fusion protein during natural or T(3)-induced metamorphosis was specifically inhibited by caspase-8 inhibitors. Our results show that tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BID and Caspases-2 and -8.

PubMed ID: 16786588
Article link: Dev Dyn

Species referenced: Xenopus laevis
Genes referenced: bax bcl2 bcl2l1 bid casp2 casp3.2 casp8 cast tnf

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