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Mol Cell Biol
1994 Jun 01;146:4244-50. doi: 10.1128/mcb.14.6.4244-4250.1994.
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Myogenic differentiation triggered by antisense acidic fibroblast growth factor RNA.
Fox JC
,
Hsu AY
,
Swain JL
.
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Acidic fibroblast growth factor (FGF) and related family members regulate differentiation in organisms as diverse as Xenopus laevis and mammals. We utilized a well-characterized model of myogenic development to directly assess the importance of endogenously produced FGF in controlling differentiation. A role for endogenous FGF is suggested by the previous finding that acidic and basic FGF abundance in cultured myocytes decreases during differentiation. In this study we inhibited the endogenous production of FGF in murine Sol 8 myoblasts by using antisense RNA and observed precocious myogenic differentiation. Exogenously supplied acidic FGF rescues this phenotype. Further results suggest that the effect of FGF on myogenic differentiation is mediated in part through inhibition of myogenin expression. These results demonstrate a direct role for endogenously synthesized growth factors in regulating myogenesis and provide support for a general role for related proteins in mammalian development.
Alterio,
Acidic and basic fibroblast growth factor mRNAs are expressed by skeletal muscle satellite cells.
1990, Pubmed
Alterio,
Acidic and basic fibroblast growth factor mRNAs are expressed by skeletal muscle satellite cells.
1990,
Pubmed
Brunetti,
Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor.
1990,
Pubmed
Burgess,
The heparin-binding (fibroblast) growth factor family of proteins.
1989,
Pubmed
Chirgwin,
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
1979,
Pubmed
Clegg,
Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.
1987,
Pubmed
Cullen,
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.
1986,
Pubmed
Edmondson,
A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.
1989,
Pubmed
Eppenberger,
The comparative enzymology of creatine kinases. I. Isolation and characterization from chicken and rabbit tissues.
1967,
Pubmed
Fox,
Auto and transactivation of FGF expression: potential mechanism for regulation of myogenic differentiation.
1993,
Pubmed
Gospodarowicz,
Effect of fibroblast growth factor on the division and fusion of bovine myoblasts.
1976,
Pubmed
Groux-Muscatelli,
Proliferating satellite cells express acidic fibroblast growth factor during in vitro myogenesis.
1990,
Pubmed
Hébert,
Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis.
1990,
Pubmed
Kimelman,
An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Lathrop,
Control by fibroblast growth factor of differentiation in the BC3H1 muscle cell line.
1985,
Pubmed
Linkhart,
Control of mouse myoblast commitment to terminal differentiation by mitogens.
1980,
Pubmed
Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed
Montarras,
Expression of MyoD1 coincides with terminal differentiation in determined but inducible muscle cells.
1989,
Pubmed
Moore,
The mRNAs encoding acidic FGF, basic FGF and FGF receptor are coordinately downregulated during myogenic differentiation.
1991,
Pubmed
Sassoon,
Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo.
1988,
Pubmed
Slack,
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.
,
Pubmed
,
Xenbase
Smith,
Measurement of protein using bicinchoninic acid.
1985,
Pubmed
Spizz,
Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.
1986,
Pubmed
Terrell,
Indirect angiogenic agents do not release fibroblast growth factors from extracellular matrix.
1991,
Pubmed
Vaidya,
Fibroblast growth factor and transforming growth factor beta repress transcription of the myogenic regulatory gene MyoD1.
1989,
Pubmed
Yutzey,
Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.
1990,
Pubmed
