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XB-ART-21240
Science 1994 May 20;2645162:1134-7.
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Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF.

Bazett-Jones DP , Leblanc B , Herfort M , Moss T .


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Xenopus UBF (xUBF) interacts with DNA by way of multiple HMG-box domains. When xUBF binds to the ribosomal promoter, the carboxyl-terminal acidic tail and amino-terminal HMG-box interact. Binding also leads to negative DNA supercoiling and the formation of a disk-like structure, the enhancesome. Within the enhancesome, an xUBF dimer makes a low-density protein core around which DNA is looped into a single 180-base pair turn, probably by in-phase bending. The enhancesome structure suggests a mechanism for xUBF-dependent recruitment of the TATA box-binding protein complex without direct interaction between the two factors.

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Species referenced: Xenopus laevis
Genes referenced: ubtf

References :
Wolffe, Architectural transcription factors. 1994, Pubmed