Kosako H , Gotoh Y , Nishida E .

Ahn, Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. 1991, Pubmed

Ahn, Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. 1991, Pubmed
Anderson, Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. 1990, Pubmed
Ashworth, The amino acid sequence of a mammalian MAP kinase kinase. 1992, Pubmed
Boguslawski, Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases. 1987, Pubmed
Boulton, ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. 1991, Pubmed
Brewster, An osmosensing signal transduction pathway in yeast. 1993, Pubmed
Crews, Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. 1992, Pubmed
Crews, The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. 1992, Pubmed
Davis, The mitogen-activated protein kinase signal transduction pathway. 1993, Pubmed
Dent, Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. 1992, Pubmed
Errede, A conserved kinase cascade for MAP kinase activation in yeast. 1993, Pubmed
Errede, MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. 1993, Pubmed
Fabian, Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes. 1993, Pubmed , Xenbase
Ferrell, Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs. 1991, Pubmed , Xenbase
Gartner, Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1. 1992, Pubmed
Gotoh, Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells. 1990, Pubmed
Gotoh, In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase. 1991, Pubmed , Xenbase
Gotoh, Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. 1991, Pubmed , Xenbase
Gotoh, Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase. 1993, Pubmed , Xenbase
Gómez, Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. 1991, Pubmed
Hattori, Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system. 1992, Pubmed , Xenbase
Hoshi, Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts. 1988, Pubmed
Howe, Activation of the MAP kinase pathway by the protein kinase raf. 1992, Pubmed
Irie, MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. 1993, Pubmed
Kameshita, A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel. 1989, Pubmed
Kosako, Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. 1992, Pubmed , Xenbase
Kosako, cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates. 1993, Pubmed , Xenbase
Kyriakis, Raf-1 activates MAP kinase-kinase. 1992, Pubmed
Lange-Carter, A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. 1993, Pubmed
Lee, A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. 1993, Pubmed , Xenbase
Leevers, Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. 1992, Pubmed
Matsuda, Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade. 1992, Pubmed , Xenbase
Matsuda, Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase. 1993, Pubmed , Xenbase
Miyasaka, Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. 1990, Pubmed
Muslin, Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos. 1993, Pubmed , Xenbase
Nadin-Davis, A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast. 1988, Pubmed
Nakielny, MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. 1992, Pubmed
Nakielny, MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction. 1992, Pubmed
Nebreda, The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo. 1993, Pubmed , Xenbase
Nebreda, The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs. 1993, Pubmed , Xenbase
Nishida, The MAP kinase cascade is essential for diverse signal transduction pathways. 1993, Pubmed , Xenbase
Otsu, Isolation of two members of the rat MAP kinase kinase gene family. 1993, Pubmed
Payne, Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). 1991, Pubmed
Posada, Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts. 1991, Pubmed , Xenbase
Posada, Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. 1993, Pubmed , Xenbase
Ray, Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. 1987, Pubmed
Sagata, Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. 1988, Pubmed , Xenbase
Seger, Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. 1992, Pubmed , Xenbase
Seger, Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. 1992, Pubmed
Shibuya, Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells. 1993, Pubmed , Xenbase
Shibuya, Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. 1992, Pubmed , Xenbase
Shirakabe, A mitogen-activated protein (MAP) kinase activating factor in mammalian mitogen-stimulated cells is homologous to Xenopus M phase MAP kinase activator. 1992, Pubmed , Xenbase
Solomon, Activation of the various cyclin/cdc2 protein kinases. 1993, Pubmed
Teague, Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases. 1986, Pubmed
Thomas, Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. 1992, Pubmed
Warbrick, The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe. 1991, Pubmed
Wood, ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. 1992, Pubmed
Wu, Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. 1993, Pubmed
Wu, Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. 1993, Pubmed
Yew, Meiotic initiation by the mos protein in Xenopus. 1992, Pubmed , Xenbase
Zheng, Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. 1993, Pubmed