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Genes Dev March 15, 2005; 19 (6): 744-55.
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To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors.

Kee Y , Bronner-Fraser M .

The neural crest is a unique population of mitotically active, multipotent progenitors that arise at the vertebrate neural plate border. Here, we show that the helix-loop-helix transcriptional regulator Id3 has a novel role in cell cycle progression and survival of neural crest progenitors in Xenopus. Id3 is localized at the neural plate border during gastrulation and neurulation, overlapping the domain of neural crest induction. Morpholino oligonucleotide-mediated depletion of Id3 results in the absence of neural crest precursors and a resultant loss of neural crest derivatives. This appears to be mediated by cell cycle inhibition followed by cell death of the neural crest progenitor pool, rather than a cell fate switch. Conversely, overexpression of Id3 increases cell proliferation and results in expansion of the neural crest domain. Our data suggest that Id3 functions by a novel mechanism, independent of cell fate determination, to mediate the decision of neural crest precursors to proliferate or die.

PubMed ID: 15769946
PMC ID: PMC1065727
Article link: Genes Dev
Grant support: [+]

Species referenced: Xenopus
Genes referenced: chrd.1 foxd3 gal.2 id2 id3 id4 neurod1 snai2 sox10 sox2 sox9 trpc2 wnt8a
Morpholinos: id2 MO1 id3 MO1

Article Images: [+] show captions
References [+] :
Andres-Barquin, Id genes in nervous system development. 2000, Pubmed