Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Low single channel conductance of the major skeletal muscle chloride channel, ClC-1.
Pusch M
,
Steinmeyer K
,
Jentsch TJ
.
???displayArticle.abstract???
We expressed the skeletal muscle chloride channel, ClC-1, in HEK293 cells and investigated it with the patch-clamp technique. Macroscopic properties are similar to those obtained after expression in Xenopus oocytes, except that faster gating kinetics are observed in mammalian cells. Nonstationary noise analysis revealed that both rat and human ClC-1 have a low single channel conductance of about 1 pS. This finding may explain the lack of single-channel data for chloride channels from skeletal muscle despite its high macroscopic chloride conductance.
Bauer,
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA.
1991, Pubmed,
Xenbase
Bauer,
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA.
1991,
Pubmed
,
Xenbase
Blatz,
Single chloride-selective channels active at resting membrane potentials in cultured rat skeletal muscle.
1985,
Pubmed
Bretag,
Muscle chloride channels.
1987,
Pubmed
Camerino,
Effects of denervation and colchicine treatment on the chloride conductance of rat skeletal muscle fibers.
1976,
Pubmed
Chen,
High-efficiency transformation of mammalian cells by plasmid DNA.
1987,
Pubmed
Chua,
Characterization of ion channels on the surface membrane of adult rat skeletal muscle.
1991,
Pubmed
Conte Camerino,
Membrane ionic conductances in normal and denervated skeletal muscle of the rat during development.
1989,
Pubmed
Doroshenko,
Novel chloride conductance in the membrane of bovine chromaffin cells activated by intracellular GTP gamma S.
1991,
Pubmed
Fahlke,
Chloride channels with reduced single-channel conductance in recessive myotonia congenita.
1993,
Pubmed
Hamill,
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
1981,
Pubmed
Hanke,
Single chloride channels from Torpedo electroplax. Activation by protons.
1983,
Pubmed
Heinemann,
Nonstationary noise analysis and application to patch clamp recordings.
1992,
Pubmed
Heiny,
Optical evidence for a chloride conductance in the T-system of frog skeletal muscle.
1990,
Pubmed
Imoto,
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance.
1988,
Pubmed
,
Xenbase
Jentsch,
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Kaupp,
Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel.
1989,
Pubmed
,
Xenbase
Koch,
The skeletal muscle chloride channel in dominant and recessive human myotonia.
1992,
Pubmed
Lewis,
Chloride channels activated by osmotic stress in T lymphocytes.
1993,
Pubmed
Miller,
A voltage-dependent chloride conductance channel from Torpedo electroplax membrane.
1980,
Pubmed
Mori,
Primary structure and functional expression from complementary DNA of a brain calcium channel.
1991,
Pubmed
,
Xenbase
Palade,
Characteristics of the chloride conductance in muscle fibers of the rat diaphragm.
1977,
Pubmed
Penner,
Regulation of calcium influx by second messengers in rat mast cells.
1988,
Pubmed
Rüdel,
Membrane changes in cells from myotonia patients.
1985,
Pubmed
Sigworth,
Sodium channels in nerve apparently have two conductance states.
1977,
Pubmed
Steinmeyer,
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.
1991,
Pubmed
,
Xenbase
Steinmeyer,
Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
1991,
Pubmed
Stühmer,
Patch clamp characterization of sodium channels expressed from rat brain cDNA.
1987,
Pubmed
,
Xenbase
Stühmer,
Potassium channels expressed from rat brain cDNA have delayed rectifier properties.
1988,
Pubmed
,
Xenbase
Verdoorn,
Functional properties of recombinant rat GABAA receptors depend upon subunit composition.
1990,
Pubmed
Weber-Schürholz,
Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle.
1993,
Pubmed
Wischmeyer,
Development of electrical myotonia in the ADR mouse: role of chloride conductance in myotubes and neonatal animals.
1993,
Pubmed
