Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-22293
Cell 1993 Aug 27;744:645-59.
Show Gene links Show Anatomy links

The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm.

Izpisúa-Belmonte JC , De Robertis EM , Storey KG , Stern CD .


???displayArticle.abstract???
The chick homeobox gene goosecoid (gsc) is first expressed in a barely noticeable cell population near the posterior margin (Koller's sickle) of the unincubated egg. Then it is detected in Hensen's node, traditionally considered the chick organizer. Later, gsc-expressing cells leave the node with the prechordal plate. Fate mapping indicates that these three regions are related by cell lineage, and transplantation experiments suggest that they all have inducing activity. Quail posterior margin and anterior primitive streak grafts (gsc expressing) induce gsc transcription in neighboring chick host cells. We propose that development of the chick organizer starts earlier than previously thought and that gsc marks this changing cell population.

???displayArticle.pubmedLink??? 7916659
???displayArticle.link??? Cell


Species referenced: Xenopus
Genes referenced: gsc