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Mol Biol Cell 1993 Jan 01;41:7-20. doi: 10.1091/mbc.4.1.7.
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Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.

Bruzzone R , Haefliger JA , Gimlich RL , Paul DL .

The cellular distribution of connexin40 (Cx40), a newly cloned gap junction structural protein, was examined by immunofluorescence microscopy using two different specific anti-peptide antibodies. Cx40 was detected in the endothelium of muscular as well as elastic arteries in a punctate pattern consistent with the known distribution of gap junctions. However, it was not detected in other cells of the vascular wall. By contrast, Cx43, another connexin present in the cardiovascular system, was not detected in endothelial cells of muscular arteries but was abundant in the myocardium and aortic smooth muscle. We have tested the ability of these connexins to interact functionally. Cx40 was functionally expressed in pairs of Xenopus oocytes and induced the formation of intercellular channels with unique voltage dependence. Unexpectedly, communication did not occur when oocytes expressing Cx40 were paired with those expressing Cx43, although each could interact with a different connexin, Cx37, to form gap junction channels in paired oocytes. These findings indicate that establishment of intercellular communication can be spatially regulated by the selective expression of different connexins and suggest a mechanism that may operate to control the extent of communication between cells.

PubMed ID: 8382974
PMC ID: PMC300896
Article link: Mol Biol Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: gja1 gja4 gja5 mgc69466

References [+] :
Baker, Effects of oligo sequence and chemistry on the efficiency of oligodeoxyribonucleotide-mediated mRNA cleavage. 1990, Pubmed, Xenbase