Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-24017
Transplantation 1992 Feb 01;532:473-6. doi: 10.1097/00007890-199202010-00039.
Show Gene links Show Anatomy links

Skin xenograft rejection in Xenopus--immunohistology and effect of thymectomy.

Horton JD , Horton TL , Ritchie P , Varley CA .


???displayArticle.abstract???
Immunohistology, using the T-lineage-specific monoclonal antibody XT-1 and an anti-IgM mAb, illustrates differences in the cellular basis of skin allograft and xenograft destruction displayed by control froglets (X. laevis). Thus T cells predominate within allografts, whereas B-lineage cells accumulate under xenografts (from X. tropicalis). The possibility that T cells do not play a central role in mediating xenograft rejection is consistent with the finding that early thymectomy (at 7 days) has minimal effect on rejection end points of X. tropicalis transplants. However, rejection of skin from a "phylogenetically less distant" xenogeneic species (X. borealis) is shown here to be impaired in early thymectomized X. laevis. Differences in the extent to which the thymus has been shown to influence skin xenograft rejection in Xenopus are discussed.

???displayArticle.pubmedLink??? 1738942
???displayArticle.link??? Transplantation


Species referenced: Xenopus
Genes referenced: ighx