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XB-ART-24471
Cell 1991 Oct 04;671:79-87.
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Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.

Smith JC , Price BM , Green JB , Weigel D , Herrmann BG .


Abstract
The Brachyury (T) gene is required for mesoderm formation in the mouse. In this paper we describe the cloning and expression of a Xenopus homolog of Brachyury, Xbra. As with Brachyury in the mouse, Xbra is expressed in presumptive mesodermal cells around the blastopore, and then in the notochord. We show that expression of Xbra occurs as a result of mesoderm induction in Xenopus, both in response to the natural signal and in response to the mesoderm-inducing factors activin A and basic FGF. Expression of Xbra in response to these factors is rapid, and will occur in dispersed cells and in the presence of a protein synthesis inhibitor, indicating that this is an "immediate-early" response to mesoderm induction.

PubMed ID: 1717160
Article link: Cell


Species referenced: Xenopus
Genes referenced: fgf2 inhba tbxt