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Development 2005 Feb 01;1324:805-16. doi: 10.1242/dev.01618.
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Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos.

Lloyd B , Tao Q , Lang S , Wylie C .

The mechanisms that control shape and rigidity of early embryos are not well understood, and yet are required for all embryonic processes to take place. In the Xenopus blastula, the cortical actin network in each blastomere is required for the maintenance of overall embryonic shape and rigidity. However, the mechanism whereby each cell assembles the appropriate pattern and number of actin filament bundles is not known. The existence of a similar network in each blastomere suggests two possibilities: cell-autonomous inheritance of instructions from the egg; or mutual intercellular signaling mediated by cell contact or diffusible signals. We show that intercellular signaling is required for the correct pattern of cortical actin assembly in Xenopus embryos, and that lysophosphatidic acid (LPA) and its receptors, corresponding to LPA1 and LPA2 in mammals, are both necessary and sufficient for this function.

PubMed ID: 15659484
Article link: Development
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actl6a lpar1 lpar2 rac1 rhoa
Morpholinos: lpar1 MO1 lpar2 MO1

Article Images: [+] show captions