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EMBO J 2006 Jun 21;2512:2792-801. doi: 10.1038/sj.emboj.7601159.
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Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation.

Charlesworth A , Wilczynska A , Thampi P , Cox LL , MacNicol AM .

A strict temporal order of maternal mRNA translation is essential for meiotic cell cycle progression in oocytes of the frog Xenopus laevis. The molecular mechanisms controlling the ordered pattern of mRNA translational activation have not been elucidated. We report a novel role for the neural stem cell regulatory protein, Musashi, in controlling the translational activation of the mRNA encoding the Mos proto-oncogene during meiotic cell cycle progression. We demonstrate that Musashi interacts specifically with the polyadenylation response element in the 3'' untranslated region of the Mos mRNA and that this interaction is necessary for early Mos mRNA translational activation. A dominant inhibitory form of Musashi blocks maternal mRNA cytoplasmic polyadenylation and meiotic cell cycle progression. Our data suggest that Musashi is a target of the initiating progesterone signaling pathway and reveal that late cytoplasmic polyadenylation element-directed mRNA translation requires early, Musashi-dependent mRNA translation. These findings indicate that Musashi function is necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cycle progression.

PubMed ID: 16763568
PMC ID: PMC1500856
Article link: EMBO J
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: mos msi1

References [+] :
Ballantyne, A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation. 1997, Pubmed, Xenbase