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Nat Neurosci 2005 Feb 01;82:179-86. doi: 10.1038/nn1380.
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Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation.

Piper M , Salih S , Weinl C , Holt CE , Harris WA .

It has been proposed that growth cones navigating through gradients adapt to baseline concentrations of guidance cues. This adaptation process is poorly understood. Using the collapse assay, we show that adaptation in Xenopus laevis retinal growth cones to the guidance cues Sema3A or netrin-1 involves two processes: a fast, ligand-specific desensitization that occurs within 2 min of exposure and is dependent on endocytosis, and a slower, ligand-specific resensitization, which occurs within 5 min and is dependent upon protein synthesis. These two phases of adaptation allow retinal axons to adjust their range of sensitivity to specific guidance cues.

PubMed ID: 15643427
PMC ID: PMC3682638
Article link: Nat Neurosci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: sema3a

References [+] :
Bassell, Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. 1998, Pubmed