Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Biochim Biophys Acta 2005 Jan 03;17392-3:251-9. doi: 10.1016/j.bbadis.2004.06.014.
Show Gene links Show Anatomy links

Transgenic animal models of tauopathies.

Lee VM , Kenyon TK , Trojanowski JQ .

Tauopathies are a group of neurodegenerative disorders that include Alzheimer''s disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology. Research advances in the last several decades have characterized and defined tau neuropathologies of both neuron and glia in these diverse disorders and this has stimulated development of animal models of tauopathies. Indeed, animal models ranging from invertebrate species such as C. elegan to Drosophila melanogaster and mammalian transgenic mouse models of tauopathies have been generated and reported. This review summarizes the salient features of many of the known models of tauopathies.

PubMed ID: 15615643
Article link: Biochim Biophys Acta

Species referenced: Xenopus
Genes referenced: mapt
GO keywords: microtubule [+]

Disease Ontology terms: Alzheimer's disease [+]