XB-ART-26235Dev Immunol 1990 Jan 01;12:85-95. doi: 10.1155/1990/67913.
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Expression of MHC class II antigens during Xenopus development.
Larval and adult forms of the amphibian Xenopus differ in their MHC class II expression. In tadpoles, class II epitopes can be detected by monoclonal antibodies only on B cells, macrophages (whatever their location), spleen reticulum, thymus epithelium, and the pharyngobuccal cavity. In contrast, all adult T cells express class II on their surface. The transitions in class II expression occur at metamorphosis and are accompanied by other changes. The skin is invaded by class II positive dendritic cells, and the skin glands differentiate and also express class II. The gut, which expressed class II in discrete areas of the embryonic tissue, becomes invaded with B cells, and its epithelium also becomes class II positive.
PubMed ID: 2136209
PMC ID: PMC2275821
Article link: Dev Immunol
Species referenced: Xenopus laevis
Genes referenced: mhc2-dma (provisional) myh6
Antibodies: Cd8 Ab1 Leukocyte Ab2 Leukocyte Ab7 Mhc2a Ab1 Mhc2a Ab2