Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-26393
FEBS Lett 1989 Nov 20;2581:119-22.
Show Gene links Show Anatomy links

Sequence and expression of a novel GABAA receptor alpha subunit.

Ymer S , Draguhn A , Köhler M , Schofield PR , Seeburg PH .


Abstract
Cloned cDNA encoding the bovine alpha 4 subunit of the GABAA receptor has been isolated. The predicted 51 amino acid long mature protein contains an exceptionally long intracellular domain and shares 53-56% sequence similarity to the previously characterized alpha 1, alpha 2 and alpha 3 subunits. Co-expression of alpha 4 and beta 1 in Xenopus oocytes resulted in the formation of GABA-gated chloride channels with expected pharmacology, although no benzodiazepine potentiation was observed. Northern analysis indicates that a 4 kb alpha 4 mRNA is expressed in the calf cerebellum, cortex and hippocampus but is barely detectable in the rat brain.

PubMed ID: 2556293
Article link:


Species referenced: Xenopus
Genes referenced: gabarap