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XB-ART-26720
Proc Natl Acad Sci U S A 1989 Jun 01;8612:4425-9.
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Mismatch repair involving localized DNA synthesis in extracts of Xenopus eggs.

Brooks P , Dohet C , Almouzni G , Méchali M , Radman M .


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Repair of heteroduplex DNA containing G.T or A.C mismatches or containing two tandem unpaired bases occurred in vitro with Xenopus egg extracts as detected by a physical assay. The repair was accompanied by a mismatch-stimulated and mismatch-localized DNA synthesis. Repaired molecules, separated from unrepaired molecules, showed a 20- to 100-fold increase in DNA synthesis in the region of the mismatch compared to regions distant from the mismatch. The remaining unrepaired heteroduplex DNA included molecules that also displayed mismatch-stimulated DNA synthesis in the mismatch-proximal regions. These may represent intermediates in the repair process. The patterns of DNA synthesis suggest that repair begins at some distance from the mismatch and that as much as 1 kilobase or more can be involved in the mismatch-stimulated synthesis.

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References [+] :
Abastado, Processing of complex heteroduplexes in Escherichia coli and Cos-1 monkey cells. 1984, Pubmed