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EMBO J
1989 Mar 01;83:695-700. doi: 10.1002/j.1460-2075.1989.tb03428.x.
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Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.
Schmieden V
,
Grenningloh G
,
Schofield PR
,
Betz H
.
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The inhibitory postsynaptic glycine receptor (GlyR) of rat spinal cord is an oligomeric transmembrane protein which forms an agonist-gated anion channel. Expression in Xenopus oocytes of its mol. wt 48,000 subunit generated glycine-gated chloride channels which were analysed by voltage clamp. The agonist and antagonist response properties as well as the desensitization characteristics of these 48 kd subunit receptors resembled GlyRs expressed from spinal cord poly(A)+ RNA. These data indicate that the 48 kd subunit is capable of assembling into a functional receptor homo-oligomer which displays the pharmacology characteristic of the spinal cord GlyR.
Akagi,
Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord.
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Akagi,
Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord.
1988,
Pubmed
,
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Aviv,
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.
1972,
Pubmed
Barker,
Amino acid pharmacology of mammalian central neurones grown in tissue culture.
1978,
Pubmed
Barker,
Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.
1978,
Pubmed
Barker,
GABA and glycine may share the same conductance channel on cultured mammalian neurones.
1979,
Pubmed
Barker,
Fluctuation analysis of neutral amino acid responses in cultured mouse spinal neurones.
1982,
Pubmed
Becker,
Glycine receptor heterogeneity in rat spinal cord during postnatal development.
1988,
Pubmed
Becker,
The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization.
1986,
Pubmed
Blair,
Single subunits of the GABAA receptor form ion channels with properties of the native receptor.
1988,
Pubmed
,
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Bormann,
Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones.
1987,
Pubmed
Boulter,
Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.
1987,
Pubmed
,
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Carpenter,
Expression of GABA and glycine receptors by messenger RNAs from the developing rat cerebral cortex.
1988,
Pubmed
,
Xenbase
Cathala,
A method for isolation of intact, translationally active ribonucleic acid.
1983,
Pubmed
Choquet,
Does beta-alanine activate more than one chloride channel associated receptor?
1988,
Pubmed
Curtis,
The hyperpolarization of spinal motoneurones by glycine and related amino acids.
1968,
Pubmed
Faber,
Voltage-dependence of glycine-activated Cl- channels: a potentiometer for inhibition?
1987,
Pubmed
Graham,
Photoaffinity-labelling of the glycine receptor of rat spinal cord.
1983,
Pubmed
Graham,
UV light-induced cross-linking of strychnine to the glycine receptor of rat spinal cord membranes.
1981,
Pubmed
Graham,
Avermectin B1a inhibits the binding of strychnine to the glycine receptor of rat spinal cord.
1982,
Pubmed
Graham,
Purification and characterization of the glycine receptor of pig spinal cord.
1985,
Pubmed
Grenningloh,
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors.
,
Pubmed
Grenningloh,
Glycine vs GABA receptors.
,
Pubmed
Gundersen,
Properties of human brain glycine receptors expressed in Xenopus oocytes.
1984,
Pubmed
,
Xenbase
Hamill,
Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA.
,
Pubmed
Houamed,
Expression of functional GABA, glycine and glutamate receptors in Xenopus oocytes injected with rat brain mRNA.
,
Pubmed
,
Xenbase
Huganir,
Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization.
,
Pubmed
Kozak,
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.
1984,
Pubmed
Langosch,
Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.
1988,
Pubmed
Levitan,
Structural and functional basis for GABAA receptor heterogeneity.
1988,
Pubmed
,
Xenbase
Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed
Olsen,
Drug interactions at the GABA receptor-ionophore complex.
1982,
Pubmed
Parker,
Responses to GABA, glycine and beta-alanine induced in Xenopus oocytes by messenger RNA from chick and rat brain.
1988,
Pubmed
,
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Pfeiffer,
Purification by affinity chromatography of the glycine receptor of rat spinal cord.
1982,
Pubmed
Pfeiffer,
Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.
1984,
Pubmed
Pritchett,
Transient expression shows ligand gating and allosteric potentiation of GABAA receptor subunits.
1988,
Pubmed
Rubin,
On the nature of allosteric transitions: implications of non-exclusive ligand binding.
1966,
Pubmed
Schmitt,
The Mr 93,000 polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein.
1987,
Pubmed
Schofield,
Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.
,
Pubmed
,
Xenbase
Sumikawa,
Partial purification and functional expression of brain mRNAs coding for neurotransmitter receptors and voltage-operated channels.
1984,
Pubmed
,
Xenbase
Young,
Strychnine binding associated with glycine receptors of the central nervous system.
1973,
Pubmed
