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XB-ART-28537
Cell 1986 Sep 26;467:1037-42.
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A CCAAT box confers cell-type-specific regulation on the Xenopus hsp70 gene in oocytes.

Bienz M .


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The Xenopus hsp70 gene is transiently heat-inducible in somatic cells; in injected oocytes, it is efficiently expressed without heat shock. I show here that this cell-type-specific and gene-specific activation is dependent on the presence of a heat shock regulatory element (HSE) and a CCAAT box in the hsp70 promoter; neither element by itself is sufficient for full activation. The same promoter elements are also required for heat inducibility in somatic cells. I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF.

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Species referenced: Xenopus laevis
Genes referenced: hsp70 hspa1l