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Proc R Soc Lond B Biol Sci 1985 Jul 22;2251238:99-106. doi: 10.1098/rspb.1985.0052.
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Messenger RNA from bovine retina induces kainate and glycine receptors in Xenopus oocytes.

Parker I , Sumikawa K , Miledi R .

The retina contains several types of nerve cells that communicate through chemical synapses. The transmitter and receptor molecules that mediate signal transmission across these synapses need further characterization. For this purpose, poly (A)+ mRNA was isolated from bovine retinas and injected into Xenopus laevis oocytes. Translation of the foreign mRNA induced the oocyte membrane to acquire functional receptors to kainate and, to a lesser extent, also receptors to glycine, gamma-aminobutryic acid (GABA), aspartate and glutamate. Thus, the cells in the retina must contain different messengers coding for these neurotransmitter receptors. Activation of the kainate receptors opens membrane channels, generating an ionic current which has an equilibrium potential close to 0 mv. The current is well maintained during prolonged application of kainate, and hence these receptors may be involved in the neurotoxic effects produced by kainate in the retina.

PubMed ID: 2863826
Article link: Proc R Soc Lond B Biol Sci