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Nucleotide sequences of H1 histone genes from Xenopus laevis. A recently diverged pair of H1 genes and an unusual H1 pseudogene.
Turner PC
,
Aldridge TC
,
Woodland HR
,
Old RW
.
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Four clones containing H1 histone gene sequences were previously isolated from a Xenopus laevis genomic library (1) and we now present the complete nucleotide sequences of these H1 genes and their flanking regions. Two of these genes code for minor H1 proteins, probably H1C, when expressed in the oocyte transcription/translation system and are present on clones with almost identical overall organization. However, at the nucleotide level these genes differ in showing base insertions and deletions, as well as substitutions. A third gene sequence which is more related to the major X. laevis H1A, corresponds to the 3' two thirds of an H1 gene. This gene has in place of a 5' coding region at least 1800 bp of apparently noncoding sequence, some of which is A-T rich. The junction does not correspond to the consensus sequence of an intron/exon boundary and therefore this H1 sequence is more likely to represent a pseudogene. Comparisons of the coding and flanking regions of these X. laevis H1 genes indicate the kind of differences which can occur among H1 subtypes within a species. A region of homology noted in the 3' noncoding portion of vertebrate histone genes is discussed in relation to the mechanism of termination of transcription.
Birchmeier,
Generation of authentic 3' termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences.
1982, Pubmed
Birchmeier,
Generation of authentic 3' termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences.
1982,
Pubmed
Bustin,
Regions of high and low cationic charge in a lysine-rich histone.
1970,
Pubmed
Corden,
Promoter sequences of eukaryotic protein-coding genes.
1980,
Pubmed
Destrée,
Analysis of histones from different tissues and embryos of Xenopus laevis (Daudin). II. Qualitative and quantitative aspects of nuclear histones during early stages of development.
1973,
Pubmed
,
Xenbase
Destrée,
Histones of Xenopus laevis erythrocytes. Purification and characterization of the lysine-rich fractions.
1979,
Pubmed
,
Xenbase
Efstratiadis,
The structure and evolution of the human beta-globin gene family.
1980,
Pubmed
Engel,
A chicken histone H3 gene contains intervening sequences.
1982,
Pubmed
Flynn,
The synthesis of histone H1 during early amphibian development.
1980,
Pubmed
,
Xenbase
Harvey,
Independently evolving chicken histone H2B genes: identification of a ubiquitous H2B-specific 5' element.
1982,
Pubmed
,
Xenbase
Hentschel,
The organization and expression of histone gene families.
1981,
Pubmed
Isenberg,
Histones.
1979,
Pubmed
Krieg,
Chicken histone H5 mRNA: the polyadenylated RNA lacks the conserved histone 3' terminator sequence.
1982,
Pubmed
Levy,
The nucleotide and amino acid coding sequence of a gene for H1 histone that interacts with euchromatin. The early embryonic H1 gene of the sea urchin Strongylocentrotus purpuratus.
1982,
Pubmed
Macleod,
The amino-acid sequence of trout-testis histone H1.
1977,
Pubmed
Maxam,
Sequencing end-labeled DNA with base-specific chemical cleavages.
1980,
Pubmed
Moorman,
Primary structure of the histone H3 and H4 genes and their flanking sequences in a minor histone gene cluster of Xenopus laevis.
1981,
Pubmed
,
Xenbase
Moorman,
Primary structure of the histone H2A and H2B genes and their flanking sequences in a minor histone gene cluster of Xenopus laevis.
1982,
Pubmed
,
Xenbase
Morris,
A comparison of the structure of chicken erythrocyte and chicken liver chromatin.
1976,
Pubmed
Newrock,
Stage-specific mRNAs coding for subtypes of H2A and H2B histones in the sea urchin embryo.
1978,
Pubmed
Noll,
Differences and similarities in chromatin structure of Neurospora crassa and higher eucaryotes.
1976,
Pubmed
Old,
Organization and expression of cloned histone gene clusters from Xenopus laevis and X. borealis.
1982,
Pubmed
,
Xenbase
Pehrson,
Bovine H10 histone subfractions contain an invariant sequence which matches histones H5 rather than H1.
1981,
Pubmed
Risley,
H1 histone variants in Xenopus laevis.
1981,
Pubmed
,
Xenbase
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Schaffner,
Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing.
1978,
Pubmed
Seiler-Tuyns,
Structure and expression in L-cells of a cloned H4 histone gene of the mouse.
1981,
Pubmed
Sharp,
Speculations on RNA splicing.
1981,
Pubmed
Stunnenberg,
Bioassay for components regulating eukaryotic gene expression: a chromosomal factor involved in the generation of histone mRNA 3' termini.
1982,
Pubmed
,
Xenbase
Turner,
H3 and H4 histone cDNA sequences from Xenopus: a sequence comparison of H4 genes.
1982,
Pubmed
,
Xenbase
Turner,
Histone gene number and organisation in Xenopus: Xenopus borealis has a homogeneous major cluster.
1983,
Pubmed
,
Xenbase
Von Holt,
More histone structures.
1979,
Pubmed
Weintraub,
The nucleosome repeat length increases during erythropoiesis in the chick.
1978,
Pubmed
Yaguchi,
Complete amino acid sequence of goose erythrocyte H5 histone and the homology between H1 and H5 histones.
1979,
Pubmed
Zernik,
Xenopus laevis histone genes: variant H1 genes are present in different clusters.
1980,
Pubmed
,
Xenbase
