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Dev Biol 1979 Jun 08;1683:441-55.
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Ultrastructural study of degeneration and regeneration in the amphibian tectum.

Ostberg A , Norden J .

The processes of degeneration and reinnervation in the optic tectum of Xenopus laevis have been detailed by quantitative ultrastructural analysis. The tecta were denervated either permanently, by removing the contralateral eye, or temporarily, by cutting the optic tract. After denervation the total number of synapses decreases rapidly within 4 days of a stable level of about 40% of the original number. Vacated postsynaptic sites are subsequently removed by phagocytosis. When regenerating axons arrive in the tectum they make synaptic contact by inducing new postsynaptic membrane specializations. The ultrastructural sequence of reinnervation by optic axons resembles initial synaptogenesis.

PubMed ID: 435978
Article link: Dev Biol

Species referenced: Xenopus laevis
Genes referenced: tecta.1 tecta.2