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XB-ART-34390
Biochem Biophys Res Commun 2006 Nov 17;3502:263-71.
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The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB.

Eto K , Eda K , Kanemoto S , Abe S .


Abstract
Neuregulin1 (NRG1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (Ig)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRG1 signaling remained unclear. In the present study, we identified a novel isoform of NRG1 containing an Ig-like domain conserved among species from adult Xenopus laevis, which is predominantly expressed in the testis and brain. We generated recombinant proteins for the whole ectodomain and EGF-like domain alone of the isoform to compare their effects on cell proliferation, and phosphorylation of and their association with ErbB receptor, demonstrating that the ectodomain had approximately 10(3)-fold higher abilities than the EGF-like domain. Therefore, the Ig-like domain is probably essential for efficient interaction of an EGF-like domain with ErbB receptors.

PubMed ID: 17007820
Article link: Biochem Biophys Res Commun


Species referenced: Xenopus laevis
Genes referenced: egf egfr erbb2 erbb3 erbb4 nrg1


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