Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Biochem Biophys Res Commun 2006 Nov 17;3502:263-71.
Show Gene links Show Anatomy links

The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB.

Eto K , Eda K , Kanemoto S , Abe S .

Neuregulin1 (NRG1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (Ig)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRG1 signaling remained unclear. In the present study, we identified a novel isoform of NRG1 containing an Ig-like domain conserved among species from adult Xenopus laevis, which is predominantly expressed in the testis and brain. We generated recombinant proteins for the whole ectodomain and EGF-like domain alone of the isoform to compare their effects on cell proliferation, and phosphorylation of and their association with ErbB receptor, demonstrating that the ectodomain had approximately 10(3)-fold higher abilities than the EGF-like domain. Therefore, the Ig-like domain is probably essential for efficient interaction of an EGF-like domain with ErbB receptors.

PubMed ID: 17007820
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: egf egfr erbb2 erbb3 erbb4 nrg1

Article Images: [+] show captions