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Development July 1, 2004; 131 (13): 3035-45.
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Xenopus Staufen is a component of a ribonucleoprotein complex containing Vg1 RNA and kinesin.

Yoon YJ , Mowry KL .

RNA localization is a key mechanism for generating cell and developmental polarity in a wide variety of organisms. We have performed studies to investigate a role for the Xenopus homolog of the double-stranded RNA-binding protein, Staufen, in RNA localization during oogenesis. We have found that Xenopus Staufen (XStau) is present in a ribonucleoprotein complex, and associates with both a kinesin motor protein and vegetally localized RNAs Vg1 and VegT. A functional role for XStau was revealed through expression of a dominant-negative version that blocks localization of Vg1 RNA in vivo. Our results suggest a central role for XStau in RNA localization in Xenopus oocytes, and provide evidence that Staufen is a conserved link between specific mRNAs and the RNA localization machinery.

PubMed ID: 15163628
Article link: Development
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: gdf1 stau1 vegt
Antibodies: Igf2bp3 Ab1

Article Images: [+] show captions