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???displayArticle.abstract??? beta-Arrestin 2 (betaarr2) is a multifunctional protein that regulates numerous aspects of G-protein-coupled receptor function. However, its possible involvement in developmental processes is poorly understood. In this work, we examined the potential role of betaarr2 during Xenopus early development. Gain- and loss-of-function studies showed that Xenopus betaarr2 (xbetaarr2) is required for proper convergent extension (CE) movements, and normal cell polarization and intercalation without affecting cell fate. Moreover, for CE movements, betaarr2 acts as an essential regulator of dishevelled-mediated PCP (planar cell polarity) signaling, but not G-protein-mediated Ca(2+) signaling. Notably, xbetaarr2 is localized with the same distribution as the dishevelled protein, which is reasonable, as xbetaarr2 is required for dishevelled activation of RhoA. Furthermore, xbetaarr2 interacts with the N-terminal quarter of Daam1 and RhoA proteins, but not Rac1, and regulates RhoA activation through Daam1 activation for CE movements. We provide evidence that the endocytic activity of xbetaarr2 is essential for control of CE movements. Taken together, our results suggest that betaarr2 has a pivotal role in the regulation of Xenopus CE movements.
Attramadal,
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
1992, Pubmed
Attramadal,
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
1992,
Pubmed
Axelrod,
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
1998,
Pubmed
,
Xenbase
Boutros,
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling.
1998,
Pubmed
Chen,
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
2003,
Pubmed
Choi,
Xenopus Cdc42 regulates convergent extension movements during gastrulation through Wnt/Ca2+ signaling pathway.
2002,
Pubmed
,
Xenbase
Davis,
Signal transduction by the JNK group of MAP kinases.
2000,
Pubmed
DeFea,
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.
2000,
Pubmed
Fanto,
Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye.
2000,
Pubmed
Ferguson,
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
1996,
Pubmed
Gaidarov,
Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding.
1999,
Pubmed
Habas,
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
2001,
Pubmed
,
Xenbase
Habas,
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
2003,
Pubmed
,
Xenbase
Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase
Heasman,
Morpholino oligos: making sense of antisense?
2002,
Pubmed
,
Xenbase
Higgs,
Formin proteins: a domain-based approach.
2005,
Pubmed
Hyodo-Miura,
XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.
2006,
Pubmed
,
Xenbase
Keller,
Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevis.
1988,
Pubmed
,
Xenbase
Kim,
JNK and ROKalpha function in the noncanonical Wnt/RhoA signaling pathway to regulate Xenopus convergent extension movements.
2005,
Pubmed
,
Xenbase
Kinoshita,
PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements.
2003,
Pubmed
,
Xenbase
Krupnick,
Arrestin/clathrin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxy terminus.
1997,
Pubmed
Kühl,
Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation.
2002,
Pubmed
,
Xenbase
Laporte,
The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.
2000,
Pubmed
Lefkowitz,
beta-arrestins: traffic cops of cell signaling.
2004,
Pubmed
Lefkowitz,
Transduction of receptor signals by beta-arrestins.
2005,
Pubmed
Lemaire,
Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.
1995,
Pubmed
,
Xenbase
Luttrell,
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
2002,
Pubmed
Malbon,
Frizzleds: new members of the superfamily of G-protein-coupled receptors.
2004,
Pubmed
McDonald,
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
2000,
Pubmed
Medina,
Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis.
2000,
Pubmed
,
Xenbase
Medina,
Interaction of Frizzled 7 and Dishevelled in Xenopus.
2000,
Pubmed
,
Xenbase
Miller,
Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation.
1999,
Pubmed
,
Xenbase
Miller,
Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways.
1999,
Pubmed
Myers,
Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity?
2002,
Pubmed
Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase
Ossipova,
Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development.
2005,
Pubmed
,
Xenbase
Park,
Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos.
2005,
Pubmed
,
Xenbase
Park,
Role of PKA as a negative regulator of PCP signaling pathway during Xenopus gastrulation movements.
2006,
Pubmed
,
Xenbase
Penzo-Mendèz,
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation.
2003,
Pubmed
,
Xenbase
Perry,
Arresting developments in heptahelical receptor signaling and regulation.
2002,
Pubmed
Polakis,
Wnt signaling and cancer.
2000,
Pubmed
Ren,
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton.
1999,
Pubmed
Rives,
Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.
2006,
Pubmed
Rothbächer,
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.
2000,
Pubmed
,
Xenbase
Seto,
Internalization is required for proper Wingless signaling in Drosophila melanogaster.
2006,
Pubmed
Sheldahl,
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos.
2003,
Pubmed
,
Xenbase
Sheldahl,
Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner.
1999,
Pubmed
,
Xenbase
Shenoy,
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.
2003,
Pubmed
Slusarski,
Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A.
1997,
Pubmed
Slusarski,
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling.
1997,
Pubmed
,
Xenbase
Spiegel,
Cell signaling. beta-arrestin--not just for G protein-coupled receptors.
2003,
Pubmed
Strutt,
The role of RhoA in tissue polarity and Frizzled signalling.
1997,
Pubmed
Tada,
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.
2000,
Pubmed
,
Xenbase
Tohgo,
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
2003,
Pubmed
Tohgo,
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
2002,
Pubmed
Unterseher,
Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.
2004,
Pubmed
,
Xenbase
Veeman,
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
2003,
Pubmed
Wallingford,
Convergent extension: the molecular control of polarized cell movement during embryonic development.
2002,
Pubmed
,
Xenbase
Wallingford,
Dishevelled controls cell polarity during Xenopus gastrulation.
2000,
Pubmed
,
Xenbase
Wallingford,
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity.
2005,
Pubmed
Weber,
Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye.
2000,
Pubmed
Wharton,
Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction.
2003,
Pubmed
Wodarz,
Mechanisms of Wnt signaling in development.
1998,
Pubmed
,
Xenbase
Yamanaka,
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates.
2002,
Pubmed
,
Xenbase
Yu,
Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.
2007,
Pubmed
,
Xenbase
