XB-ART-35927Dev Genes Evol 2007 Jul 01;2177:485-97. doi: 10.1007/s00427-007-0158-z.
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The olig family: phylogenetic analysis and early gene expression in Xenopus tropicalis.
The olig genes form a small subfamily of basic helix-loop-helix transcription factors. They were discovered in 2000 as genes required for oligodendrocyte lineage specification. Since then, olig genes have been identified in various vertebrate species and corresponding sequences accumulated within genomic databases. Until now, three groups of olig genes have been characterized. Our phylogenetic analysis demonstrates the existence of a fourth group, which we named olig4. Genes of the four olig groups are present in actinopterygians and amphibians, whereas mammals only possess olig1, 2, and 3. We also found one olig gene in hemichordates, urochordates, and cephalochordates. Our expression study during Xenopus tropicalis embryogenesis shows that the four olig genes have very distinct expression patterns. Olig1 is very faintly expressed before the tadpole stage, whereas olig2, 3, and 4 are expressed from the gastrula stage onward. The olig3 expression during neurulation suggests a role in early anteroposterior patterning of the brain. All these results indicate that olig genes are involved in several developmental processes during early development.
PubMed ID: 17554554
Article link: Dev Genes Evol
Species referenced: Xenopus tropicalis
Genes referenced: olig1 olig2 olig3 olig4
References [+] :
Amiel, Polyalanine expansions in human. 2004, Pubmed