Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Gen Comp Endocrinol 2007 Jan 01;1531-3:176-81. doi: 10.1111/j.1440-169X.2007.00927.x.
Show Gene links Show Anatomy links

Expression and physiological regulation of BDNF receptors in the neuroendocrine melanotrope cell of Xenopus laevis.

Kidane AH , van Dooren SH , Roubos EW , Jenks BG .

Brain-derived neurotrophic factor (BDNF) and alpha-melanophore-stimulating hormone (alpha-MSH) are co-sequestered in secretory granules in melanotrope cells of the pituitary pars intermedia of the amphibian Xenopus laevis. alpha-MSH is responsible for pigment dispersion in dermal melanophores during the process of black-background adaptation. BDNF-production in melanotrope cells is increased by placing animals on a black background, and BDNF acts as an autocrine stimulatory factor on the melanotrope cells. However, the repertoire of possible neurotrophin receptors of the melanotrope is unknown. In this study we have established the expression of full length TrkB (TrkB.FL), truncated TrkB (TrkB.T) and p75(NTR) receptors in the Xenopus neurointermediate lobe by RT-PCR. In situ hybridization reveals the presence of TrkB.FL mRNA and p75(NTR) mRNA in melanotrope cells. Quantitative RT-PCR shows that in animals on a black background the amounts of TrkB.T and p75(NTR) mRNA are about three times higher than in white background-adapted animals. We suggest that the amount of p75(NTR) sets the sensitivity of the melanotrope cells for the stimulatory action of BDNF during physiological adaptation to background light intensity.

PubMed ID: 17502112
Article link: Gen Comp Endocrinol

Species referenced: Xenopus laevis
Genes referenced: bdnf ngfr nradd ntrk2 ntsr1 pomc

Article Images: [+] show captions
References :
Conlon, Novel neuroendocrine peptides and their receptors and actions. 2007, Pubmed, Xenbase