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Dev Dyn October 1, 2007; 236 (10): 2852-64.
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Neural MMP-28 expression precedes myelination during development and peripheral nerve repair.

Werner SR , Mescher AL , Neff AW , King MW , Chaturvedi S , Duffin KL , Harty MW , Smith RC .

Mammalian matrix metalloproteinase 28 (MMP-28) is expressed in several normal adult tissues, and during cutaneous wound healing. We show that, in frog and mouse embryos, MMP-28 is expressed predominantly throughout the nervous system. Xenopus expression increases during neurulation and remains elevated through early limb development where it is expressed in nerves. In the mouse, neural expression peaks at embryonic day (E) 14 but remains detectable through E17. During frog hindlimb regeneration XMMP-28 is not initially expressed in the regenerating nerves but is detectable before myelination. Following hindlimb denervation, XMMP-28 expression is detectable along regenerating nerves before myelination. In embryonic rat neuron-glial co-cultures, MMP-28 decreases after the initiation of myelination. Incubation of embryonic brain tissue with purified MMP-28 leads to the degradation of multiple myelin proteins. These results suggest that MMP-28 plays an evolutionarily conserved role in neural development and is likely to modulate the axonal-glial extracellular microenvironment.

PubMed ID: 17823957
Article link: Dev Dyn

Species referenced: Xenopus laevis
Genes referenced: drg1 epha8 mag mmp28 npat slc7a5
Antibodies: Mmp28 Ab1

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