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J Neurosci January 2, 2008; 28 (1): 100-5.
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NF-protocadherin and TAF1 regulate retinal axon initiation and elongation in vivo.

Piper M , Dwivedy A , Leung L , Bradley RS , Holt CE .

NF-protocadherin (NFPC)-mediated cell-cell adhesion plays a critical role in vertebrate neural tube formation. NFPC is also expressed during the period of axon tract formation, but little is known about its function in axonogenesis. Here we have tested the role of NFPC and its cytosolic cofactor template-activating factor 1 (TAF1) in the emergence of the Xenopus retinotectal projection. NFPC is expressed in the developing retina and optic pathway and is abundant in growing retinal axons. Inhibition of NFPC function in developing retinal ganglion cells (RGCs) severely reduces axon initiation and elongation and suppresses dendrite genesis. Furthermore, an identical phenotype occurs when TAF1 function is blocked. These data provide evidence that NFPC regulates axon initiation and elongation and indicate a conserved role for TAF1, a transcriptional regulator, as a downstream cytosolic effector of NFPC in RGCs.

PubMed ID: 18171927
PMC ID: PMC3682210
Article link: J Neurosci
Grant support: [+]

Species referenced: Xenopus
Genes referenced: adm myc pcdh7 taf1

Article Images: [+] show captions
References [+] :
Bradley, NF-protocadherin, a novel member of the cadherin superfamily, is required for Xenopus ectodermal differentiation. 1998, Pubmed, Xenbase