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XB-ART-37325
Proc Natl Acad Sci U S A January 29, 2008; 105 (4): 1369-73.
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Molecular switch for CLC-K Cl- channel block/activation: optimal pharmacophoric requirements towards high-affinity ligands.

Liantonio A , Picollo A , Carbonara G , Fracchiolla G , Tortorella P , Loiodice F , Laghezza A , Babini E , Zifarelli G , Pusch M , Camerino DC .


Abstract


PubMed ID: 18216243
PMC ID: PMC2234145
Article link: Proc Natl Acad Sci U S A
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: clcnkb
GO keywords: sodium channel activity

OMIMs: BARTTER SYNDROME, TYPE 3; BARTS3
References [+] :
Akizuki, Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidney. 2001, Pubmed