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Curr Opin Genet Dev
2008 Aug 01;184:304-10. doi: 10.1016/j.gde.2008.06.001.
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Integrating positional information at the level of Smad1/5/8.
Eivers E
,
Fuentealba LC
,
De Robertis EM
.
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The intensity of the BMP signal is determined by cell surface receptors that phosphorylate Smad1/5/8 at the C-terminus. In addition to this BMP-activated phosphorylation, recent studies have shown that sequential phosphorylations by MAPK and GSK3 kinases can negatively regulate the activity of the pSmad1Cter signal. These phosphorylations in the linker region cause Smad1 to be transported to the centrosomal region, polyubiquitinylated and degraded by the proteasomal machinery. In Xenopus embryos, Wnt signals, which regulate GSK3, induce ectoderm to adopt an epidermal fate, and this Wnt effect requires an active BMP-Smad1/5/8 signaling pathway. These findings have profound implications for understanding how dorsal-ventral and anterior-posterior patterning are seamlessly integrated in the early embryonic morphogenetic field.
Akiyama-Oda,
Axis specification in the spider embryo: dpp is required for radial-to-axial symmetry transformation and sog for ventral patterning.
2006, Pubmed
Akiyama-Oda,
Axis specification in the spider embryo: dpp is required for radial-to-axial symmetry transformation and sog for ventral patterning.
2006,
Pubmed
Arendt,
Inversion of dorsoventral axis?
1994,
Pubmed
Aubin,
In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis.
2004,
Pubmed
Badano,
The centrosome in human genetic disease.
2005,
Pubmed
Beck,
The role of BMP signaling in outgrowth and patterning of the Xenopus tail bud.
2001,
Pubmed
,
Xenbase
Bilic,
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.
2007,
Pubmed
Christian,
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.
1993,
Pubmed
,
Xenbase
Cohen,
The renaissance of GSK3.
2001,
Pubmed
Conley,
Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila.
2000,
Pubmed
De Robertis,
Dorsal-ventral patterning and neural induction in Xenopus embryos.
2004,
Pubmed
,
Xenbase
De Robertis,
Gradient fields and homeobox genes.
1991,
Pubmed
De Robertis,
A common plan for dorsoventral patterning in Bilateria.
1996,
Pubmed
,
Xenbase
De Robertis,
Spemann's organizer and self-regulation in amphibian embryos.
2006,
Pubmed
De Robertis,
Evo-devo: variations on ancestral themes.
2008,
Pubmed
Feng,
Specificity and versatility in tgf-beta signaling through Smads.
2005,
Pubmed
Fuentealba,
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
2007,
Pubmed
,
Xenbase
Glinka,
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
1998,
Pubmed
,
Xenbase
Gurley,
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis.
2008,
Pubmed
Harland,
Neural induction.
2000,
Pubmed
,
Xenbase
Kiecker,
A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus.
2001,
Pubmed
,
Xenbase
Koay,
Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton.
2005,
Pubmed
Kretzschmar,
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
1997,
Pubmed
Kuroda,
Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation.
2005,
Pubmed
,
Xenbase
Lee,
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.
2006,
Pubmed
,
Xenbase
Little,
Extracellular modulation of BMP activity in patterning the dorsoventral axis.
2006,
Pubmed
,
Xenbase
Liu,
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
2002,
Pubmed
,
Xenbase
Logan,
The Wnt signaling pathway in development and disease.
2004,
Pubmed
Lowe,
Dorsoventral patterning in hemichordates: insights into early chordate evolution.
2006,
Pubmed
McGrew,
Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus.
1997,
Pubmed
,
Xenbase
Muraoka,
Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.
2006,
Pubmed
Niehrs,
Regionally specific induction by the Spemann-Mangold organizer.
2004,
Pubmed
O'Connor,
Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing.
2006,
Pubmed
Onichtchouk,
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
1999,
Pubmed
,
Xenbase
Pera,
Neural and head induction by insulin-like growth factor signals.
2001,
Pubmed
,
Xenbase
Pera,
Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.
2003,
Pubmed
,
Xenbase
Petersen,
Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration.
2008,
Pubmed
Reversade,
Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.
2005,
Pubmed
,
Xenbase
Sapkota,
Balancing BMP signaling through integrated inputs into the Smad1 linker.
2007,
Pubmed
,
Xenbase
Sater,
Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification.
2003,
Pubmed
,
Xenbase
Semenov,
LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.
2006,
Pubmed
Shi,
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
2003,
Pubmed
Stern,
Neural induction: 10 years on since the 'default model'.
2006,
Pubmed
Tucker,
The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis.
2008,
Pubmed
Wilson,
Induction of epidermis and inhibition of neural fate by Bmp-4.
1995,
Pubmed
,
Xenbase
Yu,
Axial patterning in cephalochordates and the evolution of the organizer.
2007,
Pubmed
Zeng,
Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation.
2007,
Pubmed
Zhu,
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
1999,
Pubmed
,
Xenbase
