XB-ART-3874J Neurobiol 2004 Apr 01;591:24-33. doi: 10.1002/neu.10337.
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Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development.
The semaphorin receptors neuropilin and plexin were initially identified as antigens for monoclonal antibodies MAb-A5 and MAb-B2, which bind to specific neuropiles and plexiform layers within the Xenopus tadpole nervous systems, several years before the discovery of the first semaphorin. This article provides an overview of how neuropilin and plexin were discovered. In addition, it describes the functions of neuropilin in the signaling of chemorepulsive activities of class 3 semaphorins and roles of neuropilin-mediated semaphorin activities in the directional guidance of the peripheral nervous system (PNS) and integration of the peripheral ganglia.
PubMed ID: 15007824
Article link: J Neurobiol
Species referenced: Xenopus
Genes referenced: nrp1
Antibodies: Nrp1 Ab1 Plxna1 Ab1