Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis.
Cha SW
,
Lee JW
,
Hwang YS
,
Chae JP
,
Park KM
,
Cho HJ
,
Kim DS
,
Bae YC
,
Park MJ
.
???displayArticle.abstract???
We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in Xenopus embryos. However, we still do not know whether or not the alteration of FGF signaling controls embryonic cell fate, or when FGF signal blocking is required for endoderm formation in Xenopus. Here, we show that FGF signal blocking in embryonic cells causes their descendants to move into the endodermal region and to express endodermal genes. It is also interesting that blocking FGF signaling between fertilization and embryonic stage 10.5 promotes endoderm formation, but persistent FGF signaling blocking after stage 10.5 restricts endoderm formation and differentiation.
Agius,
Endodermal Nodal-related signals and mesoderm induction in Xenopus.
2000, Pubmed,
Xenbase
Agius,
Endodermal Nodal-related signals and mesoderm induction in Xenopus.
2000,
Pubmed
,
Xenbase
Amaya,
FGF signalling in the early specification of mesoderm in Xenopus.
1993,
Pubmed
,
Xenbase
Cha,
Inhibition of FGF signaling causes expansion of the endoderm in Xenopus.
2004,
Pubmed
,
Xenbase
Ciruna,
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
2001,
Pubmed
Clements,
Mode of action of VegT in mesoderm and endoderm formation.
1999,
Pubmed
,
Xenbase
Clements,
VegT induces endoderm by a self-limiting mechanism and by changing the competence of cells to respond to TGF-beta signals.
2003,
Pubmed
,
Xenbase
Cornell,
FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction.
1995,
Pubmed
,
Xenbase
Dale,
Vertebrate development: Multiple phases to endoderm formation.
1999,
Pubmed
,
Xenbase
Dale,
Fate map for the 32-cell stage of Xenopus laevis.
1987,
Pubmed
,
Xenbase
Delaune,
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition.
2005,
Pubmed
,
Xenbase
Esner,
Targeted disruption of fibroblast growth factor receptor-1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodies.
2002,
Pubmed
Fujii,
Anteroposterior patterning in Xenopus embryos: egg fragment assay system reveals a synergy of dorsalizing and posteriorizing embryonic domains.
2002,
Pubmed
,
Xenbase
Heasman,
Patterning the Xenopus blastula.
1997,
Pubmed
,
Xenbase
Heasman,
Maternal determinants of embryonic cell fate.
2006,
Pubmed
,
Xenbase
Hilton,
VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula.
2003,
Pubmed
,
Xenbase
Kofron,
The role of Mixer in patterning the early Xenopus embryo.
2004,
Pubmed
,
Xenbase
Mohammadi,
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
1997,
Pubmed
Muñoz-Sanjuán,
Early posterior/ventral fate specification in the vertebrate embryo.
2001,
Pubmed
,
Xenbase
Patient,
The GATA family (vertebrates and invertebrates).
2002,
Pubmed
Sasai,
Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps.
1996,
Pubmed
,
Xenbase
Schohl,
A role for maternal beta-catenin in early mesoderm induction in Xenopus.
2003,
Pubmed
,
Xenbase
Stemple,
Vertebrate development: the subtle art of germ-layer specification.
2001,
Pubmed
Vincent,
Cell fate decisions within the mouse organizer are governed by graded Nodal signals.
2003,
Pubmed
Wardle,
Transcriptional regulation of mesendoderm formation in Xenopus.
2006,
Pubmed
,
Xenbase
Xanthos,
Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis.
2001,
Pubmed
,
Xenbase
