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Biochem Biophys Res Commun 2009 Jul 10;3844:491-4. doi: 10.1016/j.bbrc.2009.05.004.
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Pro-apoptotic activity and mono-/diubiquitylation of Xenopus Bid in egg extracts.

Saitoh T , Tsuchiya Y , Kinoshita T , Itoh M , Yamashita S .

Apoptosis in Xenopus egg extracts is carried out by maternally stockpiled materials, but the contributions of endogenous apoptosis regulators are still poorly characterized. Here we examined the physiological role of Xenopus Bid (xBid), a pro-apoptotic BH3-only member of Bcl-2 family proteins. We found that endogenous xBid was a physiological accelerator of apoptosis in egg extracts. Interestingly, xBid was mono-/diubiquitylated but not degraded by proteasome in egg extracts, and we identified three ubiquitylated Lys residues in the N-terminal propeptide region. Comparison with human Bid suggested that mono-/diubiquitylation is a specific feature of xBid.

PubMed ID: 19426713
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: bcl2 bid