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PLoS One May 29, 2009; 4 (5): e5742.
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Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos.

Karaulanov E , Böttcher RT , Stannek P , Wu W , Rau M , Ogata S , Cho KW , Niehrs C .

The FLRT family of transmembrane proteins has been implicated in the regulation of FGF signalling, neurite outgrowth, homotypic cell sorting and cadherin-mediated adhesion. In an expression screen we identified the Netrin receptors Unc5B and Unc5D as high-affinity FLRT3 interactors. Upon overexpression, Unc5B phenocopies FLRT3 and both proteins synergize in inducing cell deadhesion in Xenopus embryos. Morpholino knock-downs of Unc5B and FLRT3 synergistically affect Xenopus development and induce morphogenetic defects. The small GTPase Rnd1, which transmits FLRT3 deadhesion activity, physically and functionally interacts with Unc5B, and mediates its effect on cell adhesion. The results suggest that FLRT3, Unc5B and Rnd1 proteins interact to modulate cell adhesion in early Xenopus development.

PubMed ID: 19492039
PMC ID: PMC2683942
Article link: PLoS One

Species referenced: Xenopus
Genes referenced: bambi cdh3 chrd.1 dkk1 flrt3 gata2 krt12.4 myf5 myod1 not rnd1 snai1 snai2 sox3 tbxt tubb2b unc5a unc5b unc5d ventx2.2
Morpholinos: flrt3 MO2 flrt3 MO6 rnd1 MO1 unc5b MO1 unc5b MO2

Article Images: [+] show captions
References [+] :
Aoki, Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. 2000, Pubmed