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The developing embryos of the South African (Xenopus laevis) and Western (Xenopus tropicalis) clawed frogs provide an experimentally tractable and easily visualized model for vertebrate cardiovascular development. Most of the genes used to execute the cardiac developmental program are the same in frogs and humans. Experiments using Xenopus provide an underutilized but valuable complement to studies on the molecular, cellular, physiological and morphological consequences of genetic and environmental influences on cardiac disease.
Allen,
Transgenic Xenopus laevis embryos can be generated using phiC31 integrase.
2005, Pubmed,
Xenbase
Allen,
Transgenic Xenopus laevis embryos can be generated using phiC31 integrase.
2005,
Pubmed
,
Xenbase
Allen,
Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart.
2006,
Pubmed
,
Xenbase
Bartlett,
Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis.
2007,
Pubmed
,
Xenbase
Bartlett,
Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging.
2004,
Pubmed
,
Xenbase
Bowes,
Xenbase: a Xenopus biology and genomics resource.
2008,
Pubmed
,
Xenbase
Brown,
Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis.
2005,
Pubmed
,
Xenbase
Chen,
The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis.
2007,
Pubmed
,
Xenbase
Chesneau,
Transgenesis procedures in Xenopus.
2008,
Pubmed
,
Xenbase
Cleaver,
Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia.
1996,
Pubmed
,
Xenbase
Dagle,
Oligonucleotide-based strategies to reduce gene expression.
2001,
Pubmed
,
Xenbase
Dagle,
Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis.
2003,
Pubmed
,
Xenbase
Fu,
Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner.
1998,
Pubmed
,
Xenbase
Heathcote,
Common arterial trunk associated with a homeodomain mutation of NKX2.6.
2005,
Pubmed
Kolker,
Confocal imaging of early heart development in Xenopus laevis.
2000,
Pubmed
,
Xenbase
Kroll,
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.
1996,
Pubmed
,
Xenbase
Latinkić,
Distinct enhancers regulate skeletal and cardiac muscle-specific expression programs of the cardiac alpha-actin gene in Xenopus embryos.
2002,
Pubmed
,
Xenbase
Mohun,
The morphology of heart development in Xenopus laevis.
2000,
Pubmed
,
Xenbase
Moody,
Fates of the blastomeres of the 16-cell stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Newport,
A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription.
1982,
Pubmed
,
Xenbase
Ogino,
Highly efficient transgenesis in Xenopus tropicalis using I-SceI meganuclease.
2006,
Pubmed
,
Xenbase
Pan,
I-SceI meganuclease-mediated transgenesis in Xenopus.
2006,
Pubmed
,
Xenbase
Pollet,
An atlas of differential gene expression during early Xenopus embryogenesis.
2005,
Pubmed
,
Xenbase
Small,
Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.
2003,
Pubmed
,
Xenbase
Sparrow,
Regulation of the tinman homologues in Xenopus embryos.
2000,
Pubmed
,
Xenbase
Tomlinson,
Xenopus as a model organism in developmental chemical genetic screens.
2005,
Pubmed
,
Xenbase
