Rogers CD , Moody SA , Casey ES .

NS0489180 NINDS NIH HHS , NS23158 NINDS NIH HHS , R01 NS023158-22 NINDS NIH HHS , R01 NS048918-04 NINDS NIH HHS , R01 NS023158 NINDS NIH HHS , R01 NS048918 NINDS NIH HHS

Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed, Xenbase

Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed , Xenbase
Alvarez, Neural induction in whole chick embryo cultures by FGF. 1998, Pubmed , Xenbase
Alvarez-Buylla, A unified hypothesis on the lineage of neural stem cells. 2001, Pubmed
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed , Xenbase
Aruga, Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. 2002, Pubmed
Bachiller, The organizer factors Chordin and Noggin are required for mouse forebrain development. 2000, Pubmed
Bainter, Neural induction takes a transcriptional twist. 2001, Pubmed , Xenbase
Baker, Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. 1999, Pubmed , Xenbase
Balemans, Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. 2002, Pubmed , Xenbase
Barraud, Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse. 2005, Pubmed
Beddington, Induction of a second neural axis by the mouse node. 1994, Pubmed , Xenbase
Bellefroid, Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. 1998, Pubmed , Xenbase
Belo, Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. 2000, Pubmed , Xenbase
Bergsland, The establishment of neuronal properties is controlled by Sox4 and Sox11. 2006, Pubmed
Boettger, The avian organizer. 2001, Pubmed , Xenbase
Bouwmeester, Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. 1996, Pubmed , Xenbase
Brewster, Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. 1998, Pubmed , Xenbase
Brugmann, Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. 2004, Pubmed , Xenbase
Bylund, Vertebrate neurogenesis is counteracted by Sox1-3 activity. 2003, Pubmed
Cameron, Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. 2001, Pubmed
Chang, Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation. 2007, Pubmed , Xenbase
Christian, Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development. 1991, Pubmed , Xenbase
Christian, Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. 1991, Pubmed , Xenbase
Chung, Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. 2006, Pubmed
Collignon, A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. 1996, Pubmed
De Robertis, Dorsal-ventral patterning and neural induction in Xenopus embryos. 2004, Pubmed , Xenbase
Dee, Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm. 2008, Pubmed
Delaune, Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. 2005, Pubmed , Xenbase
Doetsch, Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. 1999, Pubmed
Dy, The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. 2008, Pubmed
Ebert, Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation. 2003, Pubmed
Ekonomou, Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. 2005, Pubmed
Elkins, Isolation and characterization of a novel gene, xMADML, involved in Xenopus laevis eye development. 2006, Pubmed , Xenbase
Ellis, SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. 2004, Pubmed
Episkopou, SOX2 functions in adult neural stem cells. 2005, Pubmed
Fainsod, The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. 1997, Pubmed , Xenbase
Fainsod, On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. 1994, Pubmed , Xenbase
Fantes, Mutations in SOX2 cause anophthalmia. 2003, Pubmed
Feijóo, Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. 2009, Pubmed
Feledy, Inhibitory patterning of the anterior neural plate in Xenopus by homeodomain factors Dlx3 and Msx1. 1999, Pubmed , Xenbase
Ferri, Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. 2004, Pubmed
Fetka, Neuroectodermal specification and regionalization of the Spemann organizer in Xenopus. 2000, Pubmed , Xenbase
Foerst-Potts, Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development. 1997, Pubmed
Friedle, Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos. 1998, Pubmed , Xenbase
Friedle, Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B. 2002, Pubmed , Xenbase
Fürthauer, A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. 1997, Pubmed
Gamse, Vertebrate anteroposterior patterning: the Xenopus neurectoderm as a paradigm. 2000, Pubmed , Xenbase
Gawantka, Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. 1995, Pubmed , Xenbase
Gerhart, Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development. 1989, Pubmed , Xenbase
Glavic, Xiro-1 controls mesoderm patterning by repressing bmp-4 expression in the Spemann organizer. 2001, Pubmed , Xenbase
Gomez-Skarmeta, Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. 1996, Pubmed
Gould, Neural induction and antero-posterior patterning in the amphibian embryo: past, present and future. 1997, Pubmed , Xenbase
Graham, SOX2 functions to maintain neural progenitor identity. 2003, Pubmed
Gubbay, A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. 1990, Pubmed
Guth, Having it both ways: Sox protein function between conservation and innovation. 2008, Pubmed
Gómez-Skarmeta, Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. 1998, Pubmed , Xenbase
Gómez-Skarmeta, The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4. 2001, Pubmed , Xenbase
Gómez-Skarmeta, Iroquois genes: genomic organization and function in vertebrate neural development. 2002, Pubmed
Hargrave, Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction. 1997, Pubmed , Xenbase
Hawley, Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. 1995, Pubmed , Xenbase
Heeg-Truesdell, Neural induction in Xenopus requires inhibition of Wnt-beta-catenin signaling. 2006, Pubmed , Xenbase
Hemmati-Brivanlou, Embryonic expression and functional analysis of a Xenopus activin receptor. 1992, Pubmed , Xenbase
Hemmati-Brivanlou, Inhibition of activin receptor signaling promotes neuralization in Xenopus. 1994, Pubmed , Xenbase
Hemmati-Brivanlou, Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4. 1995, Pubmed , Xenbase
Hongo, FGF signaling and the anterior neural induction in Xenopus. 1999, Pubmed , Xenbase
Hoser, Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. 2008, Pubmed
Hurtado, Neural induction in the absence of organizer in salamanders is mediated by MAPK. 2007, Pubmed , Xenbase
Hyodo-Miura, Involvement of NLK and Sox11 in neural induction in Xenopus development. 2002, Pubmed , Xenbase
Inoue, Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. 2007, Pubmed
Ishimura, Involvement of BMP-4/msx-1 and FGF pathways in neural induction in the Xenopus embryo. 2000, Pubmed , Xenbase
Kaestner, The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization. 1995, Pubmed
Kan, Sox1 acts through multiple independent pathways to promote neurogenesis. 2004, Pubmed
Katoh, Human FOX gene family (Review). 2004, Pubmed
Khokha, Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures. 2005, Pubmed , Xenbase
Kishi, Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm. 2000, Pubmed , Xenbase
Kroll, Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. 1998, Pubmed , Xenbase
Kroll, Geminin in embryonic development: coordinating transcription and the cell cycle during differentiation. 2007, Pubmed , Xenbase
Kuo, Opl: a zinc finger protein that regulates neural determination and patterning in Xenopus. 1998, Pubmed , Xenbase
Kuroda, Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. 2005, Pubmed , Xenbase
Ladher, Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4. 1996, Pubmed , Xenbase
Lamb, Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. 1995, Pubmed , Xenbase
Larabell, Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. 1997, Pubmed , Xenbase
Launay, A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers. 1996, Pubmed , Xenbase
Li, Generation of purified neural precursors from embryonic stem cells by lineage selection. 1998, Pubmed
Linker, Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists. 2004, Pubmed , Xenbase
Luo, The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. 2004, Pubmed
Malas, Sox1-deficient mice suffer from epilepsy associated with abnormal ventral forebrain development and olfactory cortex hyperexcitability. 2003, Pubmed
McGarry, Geminin, an inhibitor of DNA replication, is degraded during mitosis. 1998, Pubmed , Xenbase
McMahon, Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. 1989, Pubmed , Xenbase
McMahon, Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. 1998, Pubmed
Meinhardt, Organizer and axes formation as a self-organizing process. 2001, Pubmed , Xenbase
Miller-Bertoglio, Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. 1999, Pubmed
Miyagi, Consequence of the loss of Sox2 in the developing brain of the mouse. 2008, Pubmed
Mizuseki, SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos. 1998, Pubmed , Xenbase
Mizuseki, Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. 1998, Pubmed , Xenbase
Mohammadi, Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. 1997, Pubmed
Moody, Neural induction, neural fate stabilization, and neural stem cells. 2002, Pubmed
Nakata, Xenopus Zic family and its role in neural and neural crest development. 1998, Pubmed , Xenbase
Nakata, Xenopus Zic3, a primary regulator both in neural and neural crest development. 1997, Pubmed , Xenbase
Nieuwkoop, The "organization centre". 3. Segregation and pattern formation in morphogenetic fields. 1967, Pubmed
Nishimoto, Requirement of the MEK5-ERK5 pathway for neural differentiation in Xenopus embryonic development. 2005, Pubmed , Xenbase
Nitta, Expression of Sox1 during Xenopus early embryogenesis. 2006, Pubmed , Xenbase
Odenthal, fork head domain genes in zebrafish. 1998, Pubmed
Onichtchouk, Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm. 1998, Pubmed , Xenbase
Onichtchouk, The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm. 1996, Pubmed , Xenbase
Otte, Ectopic induction of dorsal mesoderm by overexpression of Xwnt-8 elevates the neural competence of Xenopus ectoderm. 1992, Pubmed , Xenbase
Papanayotou, A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. 2008, Pubmed
Pencea, Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain. 2001, Pubmed
Penzel, Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis. 1997, Pubmed , Xenbase
Pera, Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. 2003, Pubmed , Xenbase
Pevny, SOX genes and neural progenitor identity. 2005, Pubmed
Piccolo, Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. 1996, Pubmed , Xenbase
Pitulescu, The regulation of embryonic patterning and DNA replication by geminin. 2005, Pubmed
Rastegar, Transcriptional regulation of Xvent homeobox genes. 1999, Pubmed , Xenbase
Rentzsch, Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. 2004, Pubmed
Rex, Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. 1997, Pubmed
Ribisi, Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue in Xenopus laevis. 2000, Pubmed , Xenbase
Rizzoti, SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. 2007, Pubmed
Rizzoti, SOX3 is required during the formation of the hypothalamo-pituitary axis. 2004, Pubmed
Rodríguez-Gallardo, Targeted over-expression of FGF in chick embryos induces formation of ectopic neural cells. 1997, Pubmed , Xenbase
Rodríguez-Seguel, The Xenopus Irx genes are essential for neural patterning and define the border between prethalamus and thalamus through mutual antagonism with the anterior repressors Fezf and Arx. 2009, Pubmed , Xenbase
Rogers, Sox3 expression is maintained by FGF signaling and restricted to the neural plate by Vent proteins in the Xenopus embryo. 2008, Pubmed , Xenbase
Rogers, Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives. 2009, Pubmed , Xenbase
Sasai, Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. 1998, Pubmed
Sasai, Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995, Pubmed , Xenbase
Sato, Development of neural inducing capacity in dissociated Xenopus embryos. 1989, Pubmed , Xenbase
Schier, Axis formation and patterning in zebrafish. 2001, Pubmed
Schlosser, Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. 2008, Pubmed , Xenbase
Seo, Geminin regulates neuronal differentiation by antagonizing Brg1 activity. 2005, Pubmed , Xenbase
Seo, Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation. 2006, Pubmed
Sheng, Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. 2003, Pubmed , Xenbase
Shih, Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage. 1996, Pubmed
Sinclair, A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. 1990, Pubmed
Smith, Getting organized: new insights into the organizer of higher vertebrates. 1998, Pubmed
Smith, A nodal-related gene defines a physical and functional domain within the Spemann organizer. 1995, Pubmed , Xenbase
Spemann, Induction of embryonic primordia by implantation of organizers from a different species. 1923. 2001, Pubmed
Stedman, A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. 2009, Pubmed
Steinbeisser, Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs. 1993, Pubmed , Xenbase
Sullivan, foxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm via transcriptional repression that is dependent on the C-terminal domain. 2001, Pubmed , Xenbase
Suzuki, Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. 1997, Pubmed , Xenbase
Sölter, Characterization of a subfamily of related winged helix genes, XFD-12/12'/12" (XFLIP), during Xenopus embryogenesis. 1999, Pubmed , Xenbase
Takeda, Xenopus msx-1 regulates dorso-ventral axis formation by suppressing the expression of organizer genes. 2000, Pubmed , Xenbase
Takemoto, Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1. 2006, Pubmed
Taranova, SOX2 is a dose-dependent regulator of retinal neural progenitor competence. 2006, Pubmed
Taylor, Tcf- and Vent-binding sites regulate neural-specific geminin expression in the gastrula embryo. 2006, Pubmed , Xenbase
Tribulo, Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. 2003, Pubmed , Xenbase
Trindade, DNA-binding specificity and embryological function of Xom (Xvent-2). 1999, Pubmed , Xenbase
Tucker, Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme. 1998, Pubmed
Uchikawa, Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. 1999, Pubmed
Uchikawa, Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals. 2003, Pubmed
Ueno, A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. 1992, Pubmed , Xenbase
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Vonica, The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity. 2007, Pubmed , Xenbase
Walmsley, Negative control of Xenopus GATA-2 by activin and noggin with eventual expression in precursors of the ventral blood islands. 1994, Pubmed , Xenbase
Wang, Sox3 expression identifies neural progenitors in persistent neonatal and adult mouse forebrain germinative zones. 2006, Pubmed
Wegner, From head to toes: the multiple facets of Sox proteins. 1999, Pubmed
Wegner, From stem cells to neurons and glia: a Soxist's view of neural development. 2005, Pubmed
Weinstein, Neural induction in Xenopus laevis: evidence for the default model. 1997, Pubmed , Xenbase
Weisinger, Inhibition of BMPs by follistatin is required for FGF3 expression and segmental patterning of the hindbrain. 2008, Pubmed
Wessely, Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays. 2004, Pubmed , Xenbase
Wilson, An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo. 2000, Pubmed , Xenbase
Wilson, The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. 2001, Pubmed , Xenbase
Wilson, Induction of epidermis and inhibition of neural fate by Bmp-4. 1995, Pubmed , Xenbase
Wittler, The acquisition of neural fate in the chick. 2004, Pubmed
Xu, A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. 1995, Pubmed , Xenbase
Yabe, Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. 2003, Pubmed , Xenbase
Yamamoto, Requirement of Xmsx-1 in the BMP-triggered ventralization of Xenopus embryos. 2000, Pubmed , Xenbase
Yamamoto, Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling. 2001, Pubmed , Xenbase
Yan, foxD5 plays a critical upstream role in regulating neural ectodermal fate and the onset of neural differentiation. 2009, Pubmed , Xenbase
Zappone, Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. 2000, Pubmed
Zimmerman, The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. 1996, Pubmed , Xenbase
de Martino, Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development. 2000, Pubmed , Xenbase
de la Calle-Mustienes, Xiro homeoproteins coordinate cell cycle exit and primary neuron formation by upregulating neuronal-fate repressors and downregulating the cell-cycle inhibitor XGadd45-gamma. 2002, Pubmed , Xenbase