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Nat Struct Mol Biol
2010 Aug 01;178:926-8. doi: 10.1038/nsmb0810-926.
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A new nuclease member of the FAN club.
Huang M
,
D'Andrea AD
.
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To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.
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