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Nat Struct Mol Biol 2010 Aug 01;178:926-8. doi: 10.1038/nsmb0810-926.
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A new nuclease member of the FAN club.

Huang M , D'Andrea AD .

To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.

PubMed ID: 20683477
PMC ID: PMC2945811
Article link: Nat Struct Mol Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cope fan1 fancd2

References [+] :
Bienko, Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. 2005, Pubmed