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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.
Glinka A
,
Dolde C
,
Kirsch N
,
Huang YL
,
Kazanskaya O
,
Ingelfinger D
,
Boutros M
,
Cruciat CM
,
Niehrs C
.
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R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R-spondins bind to the orphan G-protein-coupled receptors LGR4 and LGR5 by their Furin domains. Gain- and loss-of-function experiments in mammalian cells and Xenopus embryos indicate that LGR4 and LGR5 promote R-spondin-mediated Wnt/β-catenin and Wnt/PCP signalling. R-spondin-triggered β-catenin signalling requires Clathrin, while Wnt3a-mediated β-catenin signalling requires Caveolin-mediated endocytosis, suggesting that internalization has a mechanistic role in R-spondin signalling.
Aoki,
R-spondin3 is required for mouse placental development.
2007, Pubmed
Aoki,
R-spondin3 is required for mouse placental development.
2007,
Pubmed
Barker,
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.
2010,
Pubmed
Binnerts,
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
2007,
Pubmed
Blaydon,
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
2006,
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Carmon,
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
2011,
Pubmed
Cruciat,
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.
2010,
Pubmed
,
Xenbase
Dubois,
Regulated endocytic routing modulates wingless signaling in Drosophila embryos.
2001,
Pubmed
Grigoryan,
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
2008,
Pubmed
Hassler,
Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.
2007,
Pubmed
,
Xenbase
Kazanskaya,
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
2008,
Pubmed
,
Xenbase
Kazanskaya,
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.
2004,
Pubmed
,
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Kikuchi,
Regulation of Wnt signalling by receptor-mediated endocytosis.
2007,
Pubmed
Kim,
Mitogenic influence of human R-spondin1 on the intestinal epithelium.
2005,
Pubmed
Kim,
R-Spondin family members regulate the Wnt pathway by a common mechanism.
2008,
Pubmed
Mustata,
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
2011,
Pubmed
Nam,
Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.
2006,
Pubmed
Nusse,
Wnt signaling in disease and in development.
2005,
Pubmed
Ohkawara,
An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos.
2011,
Pubmed
,
Xenbase
Ohkawara,
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
2011,
Pubmed
,
Xenbase
Parma,
R-spondin1 is essential in sex determination, skin differentiation and malignancy.
2006,
Pubmed
Speel,
Tyramide signal amplification for DNA and mRNA in situ hybridization.
2006,
Pubmed
Taelman,
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.
2010,
Pubmed
,
Xenbase
Wei,
R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.
2007,
Pubmed
,
Xenbase
Zhao,
R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway.
2009,
Pubmed
de Lau,
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
2011,
Pubmed
