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Dongwuxue Yanjiu October 1, 2011; 32 (5): 485-91.
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Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation.

Liu JT , Yang Y , Guo XG , Chen M , Ding HZ , Chen YL , Wang MR .

Accumulated evidence indicates that the activating transcription factor 4 (atf4) is a developmentally relevant gene. Here, we report on the characterization of atf4 in Xenopus embryos, which is differentially expressed in the central nervous system, eyes, blood, and the pronephros, as well as in developing endodermal organs such as the stomach, duodenum, liver, and pancreas. Ectopic expression of atf4 in the animal hemisphere of Xenopus embryos had no obvious effects on the induction of neural progenitors, but suppressed neurogenesis and eye formation without promoting apoptosis. Our data suggest that tightly controlled atf4 activities may be crucial for normal neurogenesis and early eye patterning.

PubMed ID: 22006799
Article link: Dongwuxue Yanjiu

Species referenced: Xenopus laevis
Genes referenced: atf4 irx1 otx2 pax6 rax six3 sox3 tubb2b
GO keywords: eye development [+]

Disease Ontology terms: microphthalmia

Article Images: [+] show captions