Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Genes Dev
2011 Sep 01;2517:1759-62. doi: 10.1101/gad.17594311.
Show Gene links
Show Anatomy links
Wnt signaling meets internal dissent.
Grove EA
.
???displayArticle.abstract???
In canonical Wnt signaling, β-catenin translocates to the cell nucleus, interacting with Tcf/Lef factors to activate transcription of Wnt target genes. In this issue of Genes & Development, Vacik and colleagues (pp. 1783-1795) report that a highly conserved sequence in intron 5 of Tcf7l2 conceals an internal promoter region that, when activated by Vax2, drives transcription of truncated Tcf7l2 mRNAs. The encoded Tcf7l2 protein binds to DNA, but not β-catenin, and therefore acts as a dominant-negative Wnt antagonist.
???displayArticle.pubmedLink???
21896652
???displayArticle.pmcLink???PMC3175712 ???displayArticle.link???Genes Dev ???displayArticle.grants???[+]
Aberle,
beta-catenin is a target for the ubiquitin-proteasome pathway.
1997, Pubmed
Aberle,
beta-catenin is a target for the ubiquitin-proteasome pathway.
1997,
Pubmed
Angus-Hill,
T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis.
2011,
Pubmed
Barbieri,
A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.
1999,
Pubmed
,
Xenbase
Brinkmeier,
TCF and Groucho-related genes influence pituitary growth and development.
2003,
Pubmed
Brott,
Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.
2002,
Pubmed
,
Xenbase
Daniels,
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.
2005,
Pubmed
Faro,
T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis.
2009,
Pubmed
Glinka,
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
1998,
Pubmed
,
Xenbase
Halilagic,
Retinoids control anterior and dorsal properties in the developing forebrain.
2007,
Pubmed
Hatzis,
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
2008,
Pubmed
Hsieh,
A new secreted protein that binds to Wnt proteins and inhibits their activities.
1999,
Pubmed
,
Xenbase
Huh,
Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression.
1999,
Pubmed
Hurlstone,
T-cell factors: turn-ons and turn-offs.
2002,
Pubmed
Kim,
Hedgehog-regulated localization of Vax2 controls eye development.
2006,
Pubmed
Korinek,
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
1998,
Pubmed
Lee,
Expression of the diabetes-associated gene TCF7L2 in adult mouse brain.
2009,
Pubmed
Mathew,
Connective tissue fibroblasts and Tcf4 regulate myogenesis.
2011,
Pubmed
Moon,
The promise and perils of Wnt signaling through beta-catenin.
2002,
Pubmed
,
Xenbase
Mui,
The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye.
2002,
Pubmed
Mui,
Vax genes ventralize the embryonic eye.
2005,
Pubmed
Mukhopadhyay,
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
2001,
Pubmed
,
Xenbase
Nguyen,
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
2009,
Pubmed
Niehrs,
Function and biological roles of the Dickkopf family of Wnt modulators.
2006,
Pubmed
,
Xenbase
Rattner,
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
1997,
Pubmed
Schweizer,
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors.
2003,
Pubmed
Shimogori,
Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex.
2004,
Pubmed
Shu,
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.
2009,
Pubmed
Tamai,
LDL-receptor-related proteins in Wnt signal transduction.
2000,
Pubmed
,
Xenbase
Vacik,
A novel mechanism for the transcriptional regulation of Wnt signaling in development.
2011,
Pubmed
,
Xenbase
Veien,
Canonical Wnt signaling is required for the maintenance of dorsal retinal identity.
2008,
Pubmed
Wodarz,
Mechanisms of Wnt signaling in development.
1998,
Pubmed
,
Xenbase
Ye,
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
2009,
Pubmed
Zhao,
Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain.
2010,
Pubmed
,
Xenbase
