XB-ART-44232
Nat Rev Mol Cell Biol
2011 Jun 23;127:453-9. doi: 10.1038/nrm3140.
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Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
Jullien J
,
Pasque V
,
Halley-Stott RP
,
Miyamoto K
,
Gurdon JB
.
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Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell fusion can lead to efficient reprogramming of gene expression. The egg and oocyte reprogramming process includes the exchange of somatic proteins for oocyte proteins, the post-translational modification of histones and the demethylation of DNA. These events occur in an ordered manner and on a defined timescale, indicating that reprogramming by nuclear transfer and by cell fusion rely on deterministic processes.
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RHG54943 Wellcome Trust , 079948 Wellcome Trust , 081277 Wellcome Trust , G1001690 Medical Research Council , MRC_G1001690 Medical Research Council , WT079948 Wellcome Trust , WT081277 Wellcome Trust
Species referenced: Xenopus laevis
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