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XB-ART-4446
Gene 2003 Oct 23;3171-2:157-60. doi: 10.1016/s0378-1119(03)00698-x.
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LDH-A and alpha-actin as tools to assess the effects of temperature on the vertebrate genome: some problems.

Clay O , Arhondakis S , D'Onofrio G , Bernardi G .


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In a recent paper written with the purpose of shedding light on the question of whether genomic GC levels are related to temperature in vertebrates, Ream et al. [Mol. Biol. Evol. 20 (2003) 105] offered an analysis of two sets of homologous genes: those coding for alpha-actin and lactate dehydrogenase-A (LDH-A). The conclusion was that "there is no consistent relationship between adaptation temperature and the percentage of thermal stability-enhancing G+C base pairs in protein-coding genes". We argue here that the data presented neither prove nor suggest such a conclusion because of conceptual and methodological errors.

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Species referenced: Xenopus
Genes referenced: acta2 actl6a tbx2