Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Nat Genet May 13, 2012; 44 (6): 709-13.
Show Gene links Show Anatomy links

Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.

Bonnard C , Strobl AC , Shboul M , Lee H , Merriman B , Nelson SF , Ababneh OH , Uz E , Güran T , Kayserili H , Hamamy H , Reversade B .

Using homozygosity mapping and locus resequencing, we found that alterations in the homeodomain of the IRX5 transcription factor cause a recessive congenital disorder affecting face, brain, blood, heart, bone and gonad development. We found through in vivo modeling in Xenopus laevis embryos that Irx5 modulates the migration of progenitor cell populations in branchial arches and gonads by repressing Sdf1. We further found that transcriptional control by Irx5 is modulated by direct protein-protein interaction with two GATA zinc-finger proteins, GATA3 and TRPS1; disruptions of these proteins also cause craniofacial dysmorphisms. Our findings suggest that IRX proteins integrate combinatorial transcriptional inputs to regulate key signaling molecules involved in the ontogeny of multiple organs during embryogenesis and homeostasis.

PubMed ID: 22581230
Article link: Nat Genet

Species referenced: Xenopus laevis
Genes referenced: actb actl6a cxcl12 gata3 irx3 irx5 kcnd2 pgat slc12a3 trps1 twist1
GO keywords: neural crest cell migration [+]


Article Images: [+] show captions
References [+] :
Bawle, Adult and two children with fetal methotrexate syndrome. 1998, Pubmed