Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nucleus
2011 Jan 01;26:580-90. doi: 10.4161/nucl.2.6.17960.
Show Gene links
Show Anatomy links
Barrier-to-Autointegration Factor influences specific histone modifications.
Montes de Oca R
,
Andreassen PR
,
Wilson KL
.
???displayArticle.abstract???
Defects in the nuclear envelope or nuclear 'lamina' networks cause disease and can perturb histone posttranslational (epigenetic) regulation. Barrier-to-Autointegration Factor (BAF) is an essential but enigmatic lamina component that binds lamins, LEM-domain proteins, DNA and histone H3 directly. We report that BAF copurified with nuclease-digested mononucleosomes and associated with modified histones in vivo. BAF overexpression significantly reduced global histone H3 acetylation by 18%. In cells that stably overexpressed BAF 3-fold, silencing mark H3-K27-Me1/3 and active marks H4-K16-Ac and H4-Ac5 decreased significantly. Significant increases were also seen for silencing mark H3-K9-Me3, active marks H3-K4-Me2, H3-K9/K14-Ac and H4-K5-Ac and a mark (H3-K79-Me2) associated with both active and silent chromatin. Other increases (H3-S10-P, H3-S28-P and silencing mark H3-K9-Me2) did not reach statistical significance. BAF overexpression also significantly influenced cell cycle distribution. Moreover, BAF associated in vivo with SET/I2PP2A (protein phosphatase 2A inhibitor; blocks H3 dephosphorylation) and G9a (H3-K9 methyltransferase), but showed no detectable association with HDAC1 or HATs. These findings reveal BAF as a novel epigenetic regulator and are discussed in relation to BAF deficiency phenotypes, which include a hereditary progeria syndrome and loss of pluripotency in embryonic stem cells.
Andreassen,
Analysis of the spindle-assembly checkpoint in HeLa cells.
2004, Pubmed
Andreassen,
Analysis of the spindle-assembly checkpoint in HeLa cells.
2004,
Pubmed
Andreassen,
Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells.
1994,
Pubmed
Bengtsson,
Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo.
2006,
Pubmed
,
Xenbase
Berger,
The complex language of chromatin regulation during transcription.
2007,
Pubmed
Bolden,
Anticancer activities of histone deacetylase inhibitors.
2006,
Pubmed
Bradley,
Structural basis for DNA bridging by barrier-to-autointegration factor.
2005,
Pubmed
Cayrou,
Programming DNA replication origins and chromosome organization.
2010,
Pubmed
Clayton,
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation.
2000,
Pubmed
Collins,
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
2008,
Pubmed
Columbaro,
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.
2005,
Pubmed
Cox,
Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells.
2011,
Pubmed
Davis,
Monoclonal antibodies to mitotic cells.
1983,
Pubmed
,
Xenbase
Dechat,
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.
2008,
Pubmed
Delbarre,
The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers.
2006,
Pubmed
Filesi,
Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy.
2005,
Pubmed
Foltz,
The human CENP-A centromeric nucleosome-associated complex.
2006,
Pubmed
Furukawa,
Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila.
2003,
Pubmed
Gant,
Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2beta proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts.
1999,
Pubmed
,
Xenbase
Goldman,
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.
2004,
Pubmed
Gorjánácz,
Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly.
2007,
Pubmed
Guelen,
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.
2008,
Pubmed
Haraguchi,
Nuclear localization of barrier-to-autointegration factor is correlated with progression of S phase in human cells.
2007,
Pubmed
Haraguchi,
BAF is required for emerin assembly into the reforming nuclear envelope.
2001,
Pubmed
Haraguchi,
Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly.
2008,
Pubmed
Herrera,
Histone H1 is a specific repressor of core histone acetylation in chromatin.
2000,
Pubmed
Holaska,
Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro.
2003,
Pubmed
Jenuwein,
Translating the histone code.
2001,
Pubmed
Jiang,
Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes.
2008,
Pubmed
Jørgensen,
The histone methyltransferase SET8 is required for S-phase progression.
2007,
Pubmed
Kim,
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.
2004,
Pubmed
Lachner,
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
2001,
Pubmed
Li,
Interphase cell cycle dynamics of a late-replicating, heterochromatic homogeneously staining region: precise choreography of condensation/decondensation and nuclear positioning.
1998,
Pubmed
Lim,
Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.
2005,
Pubmed
Liu,
MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.
2003,
Pubmed
Luger,
Crystal structure of the nucleosome core particle at 2.8 A resolution.
1997,
Pubmed
Mamada,
Involvement of an inner nuclear membrane protein, Nemp1, in Xenopus neural development through an interaction with the chromatin protein BAF.
2009,
Pubmed
,
Xenbase
Margalit,
Barrier-to-autointegration factor--a BAFfling little protein.
2007,
Pubmed
Margalit,
Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans.
2007,
Pubmed
Margalit,
Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina.
2005,
Pubmed
McBryant,
Multifunctionality of the linker histones: an emerging role for protein-protein interactions.
2010,
Pubmed
Meister,
The spatial dynamics of tissue-specific promoters during C. elegans development.
2010,
Pubmed
Montes de Oca,
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
2009,
Pubmed
Montes de Oca,
Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1.
2005,
Pubmed
Nowak,
Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster.
2003,
Pubmed
Nowak,
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation.
2004,
Pubmed
Park,
Histone chaperones in nucleosome eviction and histone exchange.
2008,
Pubmed
Pegoraro,
Ageing-related chromatin defects through loss of the NURD complex.
2009,
Pubmed
Peric-Hupkes,
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.
2010,
Pubmed
Pickersgill,
Characterization of the Drosophila melanogaster genome at the nuclear lamina.
2006,
Pubmed
Postnikov,
Regulation of chromatin structure and function by HMGN proteins.
2010,
Pubmed
Prokocimer,
Nuclear lamins: key regulators of nuclear structure and activities.
2009,
Pubmed
Puente,
Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.
2011,
Pubmed
Rai,
Dnmt3 and G9a cooperate for tissue-specific development in zebrafish.
2010,
Pubmed
Reddy,
Transcriptional repression mediated by repositioning of genes to the nuclear lamina.
2008,
Pubmed
Sabatelli,
Nuclear alterations in autosomal-dominant Emery-Dreifuss muscular dystrophy.
2001,
Pubmed
Scaffidi,
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome.
2005,
Pubmed
Segura-Totten,
Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.
2002,
Pubmed
,
Xenbase
Shimi,
Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells.
2004,
Pubmed
Shumaker,
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.
2006,
Pubmed
Simon,
The nucleoskeleton as a genome-associated dynamic 'network of networks'.
2011,
Pubmed
Sims,
Histone lysine methylation: a signature for chromatin function.
2003,
Pubmed
Skoko,
Barrier-to-autointegration factor (BAF) condenses DNA by looping.
2009,
Pubmed
Steger,
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
2008,
Pubmed
Tachibana,
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.
2001,
Pubmed
Tardat,
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase.
2007,
Pubmed
Taverna,
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
2007,
Pubmed
Towbin,
Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner.
2010,
Pubmed
Ueda,
Distinct domains in high mobility group N variants modulate specific chromatin modifications.
2006,
Pubmed
Umland,
Structural basis of DNA bridging by barrier-to-autointegration factor.
2000,
Pubmed
Wang,
Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function.
2002,
Pubmed
Wang,
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.
1999,
Pubmed
Wen,
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells.
2009,
Pubmed
Widrow,
Very late DNA replication in the human cell cycle.
1998,
Pubmed
Wiebe,
Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication.
2007,
Pubmed
Wilson,
Lamin-binding Proteins.
2010,
Pubmed
Wilson,
The nuclear envelope at a glance.
2010,
Pubmed
Worman,
Laminopathies and the long strange trip from basic cell biology to therapy.
2009,
Pubmed
Zheng,
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex.
2000,
Pubmed
Zhou,
Epigenetic control of replication origins.
2005,
Pubmed
