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XB-ART-45657
Int J Dev Biol January 1, 2012; 56 (5): 385-91.
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Expression of serotonergic system components during early Xenopus embryogenesis.

Nikishin DA , Kremnyov SV , Konduktorova VV , Shmukler YB .


Abstract
Despite abundant research studies on the physiological and biochemical nature of embryonic neurotransmitter function, little is known about the molecular genetic mechanisms involved. The expression of the main components of the serotonergic system during early Xenopus embryogenesis was investigated using RT-PCR, real time PCR and in situ hybridization. Transcripts encoding the serotonin receptors HTR2C and HTR7, as well as the vesicular monoamine transporter VMAT2, the serotonin transporter (SERT) and the serotonin synthesis enzymes tryptophan hydroxylase (TPH2) and aromatic amino acid decarboxylase (AAAD) were found to be expressed during the cleavage division stages, whereas the degradation enzyme monoamine oxidase A (MAOA) was absent. The main components of the serotonergic system were found to be expressed during the earliest stages of embryonic development. The embryonic transmitter mechanism, its complexity, and its variability among various species are discussed.

PubMed ID: 22811272
Article link: Int J Dev Biol


Species referenced: Xenopus laevis
Genes referenced: htr1a htr2b htr2c htr3a htr4 htr7 htr7l maoa odc1 slc18a2 slc6a4l tbx2 tph1 tph2


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