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Nat Neurosci February 1, 2013; 16 (2): 166-73.
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Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation.

Leung LC , Urbančič V , Baudet ML , Dwivedy A , Bayley TG , Lee AC , Harris WA , Holt CE .

Cell adhesion molecules and diffusible cues both regulate axon pathfinding, yet how these two modes of signaling interact is poorly understood. The homophilic cell adhesion molecule NF-protocadherin (NFPC) is expressed in the mid-dorsal optic tract neuroepithelium and in the axons of developing retinal ganglion cells (RGC) in Xenopus laevis. Here we report that targeted disruption of NFPC function in RGC axons or the optic tract neuroepithelium results in unexpectedly localized pathfinding defects at the caudal turn in the mid-optic tract. Semaphorin 3A (Sema3A), which lies adjacent to this turn, stimulates rapid, protein synthesis-dependent increases in growth cone NFPC and its cofactor, TAF1, in vitro. In vivo, growth cones exhibit marked increases in NFPC translation reporter activity in this mid-optic tract region that are attenuated by blocking neuropilin-1 function. Our results suggest that translation-linked coupling between regionally localized diffusible cues and cell adhesion can help axons navigate discrete segments of the pathway.

PubMed ID: 23292679
PMC ID: PMC3701881
Article link: Nat Neurosci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: nrp1 pcdh7 sema3a taf1

References [+] :
Arikkath, Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. 2008, Pubmed