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Cytogenet Genome Res 2002 Jan 01;991-4:229-35. doi: 10.1159/000071598.
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The role of ZIC3 in vertebrate development.

Herman GE , El-Hodiri HM .

ZIC3 is a C2H2 zinc finger transcription factor that is involved in early patterning of the vertebrate embryo. Human patients with mutations in the X-linked ZIC3 gene have a complex developmental phenotype that includes laterality defects, congenital heart disease, and lumbosacral and anal anomalies, including neural tube defects. Similar phenotypes are found in the bent tail (BN) mouse, a spontaneous mutation that is associated with a submicroscopic deletion of the ZIC3 locus, as well as in a ZIC3 null allele generated through homologous recombination. These findings suggest that ZIC3 plays important roles during development in establishing a proper left-right axis and in midline neural patterning. This review will summarize our current understanding of the role of ZIC3 in patterning of the vertebrate embryo, based on studies in model organisms such as Xenopus and the mouse. In addition, a comparison of ZIC3 with other vertebrate ZIC family members will be provided.

PubMed ID: 12900569
Article link: Cytogenet Genome Res

Species referenced: Xenopus
Genes referenced: zic3
GO keywords: left/right pattern formation

Disease Ontology terms: visceral heterotaxy [+]