XB-ART-49108Dev Dyn 2014 Jan 01;2431:76-87. doi: 10.1002/dvdy.24075.
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Glimpse into Hox and tale regulation of cell differentiation and reprogramming.
During embryonic development, cells become gradually restricted in their developmental potential and start elaborating lineage-specific transcriptional networks to ultimately acquire a unique differentiated state. Hox genes play a central role in specifying regional identities, thereby providing the cell with critical information on positional value along its differentiation path. The exquisite DNA-binding specificity of the Hox proteins is frequently dependent upon their interaction with members of the TALE family of homeodomain proteins. In addition to their function as Hox-cofactors, TALE homeoproteins control multiple crucial developmental processes through Hox-independent mechanisms. Here, we will review recent findings on the function of both Hox and TALE proteins in cell differentiation, referring mostly to vertebrate species. In addition, we will discuss the direct implications of this knowledge on cell plasticity and cell reprogramming.
PubMed ID: 24123411
Article link: Dev Dyn
Species referenced: Xenopus
Genes referenced: irx2 meis1 meis2 meis3 pbx1 pbx2 tgif1 tgif2
Article Images: [+] show captions
|Figure 1. Expression of selected TALE homeodomain genes in the mouse digestive system. Expression of selected TALE homeodomain genes in embryonic and adult stomach, liver, pancreas, and intestine is depicted in the heat-map. Color code and intensity correspond to the relative level of expression of each gene, from not detectable (white) to high (red). ND: not determined. The expression data represented were obtained from either RNA-Seq or RT-qPCR analyses (Rodríguez-Seguel et al., 2013) (Cerdá-Esteban and Spagnoli, unpublished results), and available published literature (http://www.genepaint.org/Frameset.html).Download figure to PowerPoint|