XB-ART-49446
Curr Opin Cell Biol
2014 Jun 01;28:16-27.
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Sizing and shaping the nucleus: mechanisms and significance.
Jevtić P
,
Edens LJ
,
Vuković LD
,
Levy DL
.
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The size and shape of the nucleus are tightly regulated, indicating the physiological significance of proper nuclear morphology, yet the mechanisms and functions of nuclear size and shape regulation remain poorly understood. Correlations between altered nuclear morphology and certain disease states have long been observed, most notably many cancers are diagnosed and staged based on graded increases in nuclear size. Here we review recent studies investigating the mechanisms regulating nuclear size and shape, how mitotic events influence nuclear morphology, and the role of nuclear size and shape in subnuclear chromatin organization and cancer progression.
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References [+] :
Abrams,
Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development.
2012, Pubmed
Abrams, Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. 2012, Pubmed
Albert, Systematic characterization of the conformation and dynamics of budding yeast chromosome XII. 2013, Pubmed
Anderson, Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. 2008, Pubmed
Asencio, Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. 2012, Pubmed
Barascu, Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. 2012, Pubmed
Bickmore, Genome architecture: domain organization of interphase chromosomes. 2013, Pubmed
Bifulco, N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A. 2013, Pubmed
Buster, SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2. 2013, Pubmed
Butler, Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells. 2009, Pubmed
Cacciola, Nuclear size as estrogen-responsive chromatin quality parameter of mouse spermatozoa. 2013, Pubmed
Campbell, Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion. 2006, Pubmed
Cao, Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. 2011, Pubmed
Chai, Field effect in cancer-an update. 2009, Pubmed
Chambliss, Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution. 2013, Pubmed
Chan, How cells know the size of their organelles. 2012, Pubmed
Chen, Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. 2012, Pubmed
Chmielewska, Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope. 2011, Pubmed , Xenbase
Chow, The nuclear envelope environment and its cancer connections. 2012, Pubmed
Coffinier, Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. 2011, Pubmed
Crasta, DNA breaks and chromosome pulverization from errors in mitosis. 2012, Pubmed
Dittmer, LITTLE NUCLEI genes affecting nuclear morphology in Arabidopsis thaliana. 2007, Pubmed
Driscoll, Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell? 2012, Pubmed
Edens, Nuclear size regulation: from single cells to development and disease. 2013, Pubmed , Xenbase
Feric, A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells. 2013, Pubmed , Xenbase
Fernandez-Martinez, Nuclear pore complex biogenesis. 2009, Pubmed
Finan, The effects of osmotic stress on the structure and function of the cell nucleus. 2010, Pubmed
Finan, Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. 2011, Pubmed
Friederichs, The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. 2011, Pubmed
Friedl, Nuclear mechanics during cell migration. 2011, Pubmed
Funkhouser, Mechanical model of blebbing in nuclear lamin meshworks. 2013, Pubmed
Gant, Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2beta proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts. 1999, Pubmed , Xenbase
Gay, RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. 2011, Pubmed
Goehring, Organelle growth control through limiting pools of cytoplasmic components. 2012, Pubmed
Golden, Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope. 2009, Pubmed
Gonzalez, Nuclear shape, growth and integrity in the closed mitosis of fission yeast depend on the Ran-GTPase system, the spindle pole body and the endoplasmic reticulum. 2009, Pubmed
Good, Cytoplasmic volume modulates spindle size during embryogenesis. 2013, Pubmed , Xenbase
Gupta, Role of actin dependent nuclear deformation in regulating early gene expression. 2012, Pubmed
Hampoelz, Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos. 2011, Pubmed
Hara, Cell-size-dependent control of organelle sizes during development. 2011, Pubmed
Hara, Intranuclear DNA density affects chromosome condensation in metazoans. 2013, Pubmed , Xenbase
Hatch, Catastrophic nuclear envelope collapse in cancer cell micronuclei. 2013, Pubmed
Hattier, Immobility, inheritance and plasticity of shape of the yeast nucleus. 2007, Pubmed
Hazel, Changes in cytoplasmic volume are sufficient to drive spindle scaling. 2013, Pubmed , Xenbase
Ibrahim, Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. 2013, Pubmed
Imbalzano, Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections. 2013, Pubmed
Jain, Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility. 2013, Pubmed
Kang, A dynamical model reveals gene co-localizations in nucleus. 2011, Pubmed
Khatau, The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells. 2012, Pubmed
Khatau, A perinuclear actin cap regulates nuclear shape. 2009, Pubmed
Kieserman, Mitotic chromosome size scaling in Xenopus. 2011, Pubmed , Xenbase
Kiseleva, Reticulon 4a/NogoA locates to regions of high membrane curvature and may have a role in nuclear envelope growth. 2007, Pubmed , Xenbase
Lee, Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. 2012, Pubmed
Levy, Mechanisms of intracellular scaling. 2012, Pubmed , Xenbase
Levy, Nuclear size is regulated by importin α and Ntf2 in Xenopus. 2010, Pubmed , Xenbase
Li, Biophysical regulation of histone acetylation in mesenchymal stem cells. 2011, Pubmed
Libault, A member of the highly conserved FWL (tomato FW2.2-like) gene family is essential for soybean nodule organogenesis. 2010, Pubmed
Liu, Microfluidic platforms for single-cell protein analysis. 2013, Pubmed
Lovett, Modulation of Nuclear Shape by Substrate Rigidity. 2013, Pubmed
Lu, Nesprin interchain associations control nuclear size. 2012, Pubmed
Lüke, Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. 2008, Pubmed
Maeshima, Nuclear size, nuclear pore number and cell cycle. 2011, Pubmed
Maeshima, Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. 2010, Pubmed
Martins, Mechanical regulation of nuclear structure and function. 2012, Pubmed
Meister, The spatial dynamics of tissue-specific promoters during C. elegans development. 2010, Pubmed
Miedema, Image and statistical analysis of melanocytic histology. 2012, Pubmed
Mijaljica, Nucleophagy at a glance. 2013, Pubmed
Nandakumar, Isotropic 3D nuclear morphometry of normal, fibrocystic and malignant breast epithelial cells reveals new structural alterations. 2012, Pubmed
Naumova, Integrating one-dimensional and three-dimensional maps of genomes. 2010, Pubmed
Newport, A lamin-independent pathway for nuclear envelope assembly. 1990, Pubmed , Xenbase
Niepel, The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. 2013, Pubmed
O'Brien, TPX2 is required for postmitotic nuclear assembly in cell-free Xenopus laevis egg extracts. 2006, Pubmed , Xenbase
Oda, Dynamics of Arabidopsis SUN proteins during mitosis and their involvement in nuclear shaping. 2011, Pubmed
Okudela, An association between nuclear morphology and immunohistochemical expression of p53 and p16INK4A in lung cancer cells. 2014, Pubmed
Olins, An in vitro model for Pelger-Huët anomaly: stable knockdown of lamin B receptor in HL-60 cells. 2010, Pubmed
Pemberton, Disruption of the nucleoporin gene NUP133 results in clustering of nuclear pore complexes. 1995, Pubmed
Polychronidou, Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane. 2010, Pubmed
Prokocimer, Nuclear lamins: key regulators of nuclear structure and activities. 2009, Pubmed
Prüfert, The lamin CxxM motif promotes nuclear membrane growth. 2004, Pubmed , Xenbase
Ralle, Intranuclear membrane structure formations by CaaX-containing nuclear proteins. 2004, Pubmed , Xenbase
Reddy, Higher order chromatin organization in cancer. 2013, Pubmed
Rowat, Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. 2013, Pubmed
Rozwadowska, Characterisation of nuclear architectural alterations during in vitro differentiation of human stem cells of myogenic origin. 2013, Pubmed
Samarnthai, Pathologic changes in breast cancer after anti-estrogen therapy. 2012, Pubmed
Schlaitz, REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. 2013, Pubmed
Schooley, Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation. 2012, Pubmed
Schuster-Böckler, Chromatin organization is a major influence on regional mutation rates in human cancer cells. 2012, Pubmed
Shaulov, A dominant-negative form of POM121 binds chromatin and disrupts the two separate modes of nuclear pore assembly. 2011, Pubmed , Xenbase
Shumaker, Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy. 2005, Pubmed , Xenbase
Shuto, Significant Correlation between Chromosomal Aberration and Nuclear Morphology in Urothelial Carcinoma. 2012, Pubmed
Siniossoglou, Lipins, lipids and nuclear envelope structure. 2009, Pubmed
Skvortsov, Proteomics profiling of microdissected low- and high-grade prostate tumors identifies Lamin A as a discriminatory biomarker. 2011, Pubmed
Smoyer, Breaking down the wall: the nuclear envelope during mitosis. 2014, Pubmed
Swift, Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. 2013, Pubmed
Tamiello, Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations. 2013, Pubmed
Tamura, Involvement of the nuclear pore complex in morphology of the plant nucleus. 2011, Pubmed
Tamura, Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. 2010, Pubmed
Tapley, Connecting the nucleus to the cytoskeleton by SUN-KASH bridges across the nuclear envelope. 2013, Pubmed
Theerthagiri, The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. 2010, Pubmed , Xenbase
Titus, Members of the RSC chromatin-remodeling complex are required for maintaining proper nuclear envelope structure and pore complex localization. 2010, Pubmed
Tran, A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect. 2012, Pubmed
Vargas, Transient nuclear envelope rupturing during interphase in human cancer cells. 2012, Pubmed
Veltri, Nuclear morphometry, nucleomics and prostate cancer progression. 2012, Pubmed
Versaevel, Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. 2012, Pubmed
Walters, Shaping the nucleus: factors and forces. 2012, Pubmed
Wang, RNA-Seq: a revolutionary tool for transcriptomics. 2009, Pubmed
Wang, Bio-inspired encapsulation and functionalization of living cells with artificial shells. 2014, Pubmed
Wang, Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome. 2010, Pubmed
Webster, Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation. 2010, Pubmed
Webster, Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly. 2009, Pubmed
Wente, NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure. 1994, Pubmed
Winey, Mitotic spindle form and function. 2012, Pubmed
Witkin, The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. 2012, Pubmed
Wolf, Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. 2013, Pubmed
Wren, Modeling nuclear blebs in a nucleoskeleton of independent filament networks. 2012, Pubmed
Xue, Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. 2013, Pubmed , Xenbase
Yam, Partitioning and remodeling of the Schizosaccharomyces japonicus mitotic nucleus require chromosome tethers. 2013, Pubmed
Yazdani, Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons. 2012, Pubmed
Zeimet, DNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer. 2011, Pubmed
Zhang, Remodeling the nuclear membrane during closed mitosis. 2013, Pubmed
Zhou, Novel plant SUN-KASH bridges are involved in RanGAP anchoring and nuclear shape determination. 2012, Pubmed
Zumbusch, Nonlinear vibrational microscopy applied to lipid biology. 2013, Pubmed
Zwerger, Nuclear mechanics in disease. 2011, Pubmed
van Zanten, Seed maturation in Arabidopsis thaliana is characterized by nuclear size reduction and increased chromatin condensation. 2011, Pubmed